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首页> 外文期刊>Advances in Medicine >Basal Insulin Dose in Adults with Type 1 Diabetes Mellitus on Insulin Pumps in Real-Life Clinical Practice: A Single-Center Experience
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Basal Insulin Dose in Adults with Type 1 Diabetes Mellitus on Insulin Pumps in Real-Life Clinical Practice: A Single-Center Experience

机译：现实生活中胰岛素泵上成人1型糖尿病患者的基础胰岛素剂量：单中心经验

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Introduction. Basal insulin (BI) infusion in pump therapy of type 1 diabetes (T1DM) mimics physiological secretion during the night and between meals. The recommended percentage of the total BI to daily insulin dose (termed the %BI) ranges between 30 and 50%. We analyzed whether this recommendation was followed in adults with T1DM from a university center, and whether BI doses were linked with glycemic control. Materials and Methods. We included 260 consecutive patients with T1DM (159 women and 101 men) treated with continuous subcutaneous insulin infusion at the Department of Metabolic Diseases, Krakow, Poland. Data were downloaded from patients’ pumps and collected from medical records. We analyzed the settings of BI and the association of %BI with HbA1c level. Linear regression was performed. Results. The mean age of T1DM individuals was 26.6?±?8.2 years, BMI was 23.1?±?3.0?kg/m2, T1DM duration was 13.3?±?6.4 years, and HbA1c level was 7.4%. There were 69.6% () of T1DM patients with %BI in the recommended range. The T1DM duration and HbA1c level of patients with a %BI 30% () was 9.5 years and 6.4%, respectively; for a %BI of 30–50%, it was 13.2 years and 7.4%; and for a %BI 50% (), it was 15.8 years and 7.8% ( for both three-group comparisons). Multiple regression identified %BI among independent predictors of the HbA1c level. Conclusion. In this real-life analysis, the recommendations concerning %BI dosing were not followed by almost one-third of adult T1DM patients. Low %BI was associated with better glycemic control; however, this requires further confirmation.
机译：介绍。 1型糖尿病（T1DM）泵疗法中的基础胰岛素（BI）输注模仿了夜间和两餐之间的生理分泌。总BI与每日胰岛素剂量的建议百分比（称为％BI）介于30％和50％之间。我们分析了来自大学中心的患有T1DM的成年人是否遵循了这一建议，以及BI剂量是否与血糖控制有关。材料和方法。我们纳入了波兰克拉科夫代谢疾病部门连续260例接受连续皮下胰岛素输注治疗的T1DM患者（159名女性和101名男性）。数据是从患者的泵中下载并从病历中收集的。我们分析了BI的设置以及％BI与HbA1c水平的关联。进行线性回归。结果。 T1DM患者的平均年龄为26.6±±8.2岁，BMI为23.1±±3.0μkg/ m2，T1DM持续时间为13.3±±6.4岁，HbA1c水平为7.4％。 T1DM患者中有69.6％（％）的BI在推荐范围内。 ％BI <30％（）的患者的T1DM持续时间和HbA1c水平分别为9.5年和6.4％;对于30-50％的BI百分比，分别为13.2年和7.4％;对于％BI> 50％（），分别为15.8年和7.8％（两个三组比较）。多元回归分析确定了HbA1c水平的独立预测因素中的％BI。结论。在此现实生活分析中，几乎没有三分之一的成年T1DM患者遵循有关％BI剂量的建议。低％BI与更好的血糖控制有关;但是，这需要进一步确认。

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