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首页> 外文期刊>Advances in Interventional Cardiology: Postepy w Kardiologii Interwencyjnej >Original paper The relationship between neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and thrombolysis in myocardial infarction risk score in patients with ST elevation acute myocardial infarction before primary coronary intervention
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Original paper The relationship between neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and thrombolysis in myocardial infarction risk score in patients with ST elevation acute myocardial infarction before primary coronary intervention

机译：冠心病介入治疗ST段抬高急性心肌梗死患者中性粒细胞与淋巴细胞比，血小板与淋巴细胞比与溶栓与心肌梗死危险性评分的关系

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Introduction: The thrombolysis in myocardial infarction (TIMI) risk score is calculated as the sum of independent predictors of mortality and ischemic events in ST elevation acute myocardial infarction (STEMI). Several studies show that the neutrophil to lymphocyte ratio (NLR) is a prognostic inflammatory marker. In preliminary studies, platelet to lymphocyte ratio (PLR) has been proposed as a pro-thrombotic marker. The relationship between NLR, PLR and TIMI risk score for STEMI has never been studied. Aim: To evaluate the association between TIMI-STEMI risk score and NLR, PLR and other biochemical indices in STEMI. Material and methods: In this retrospective study, we evaluated 390 patients who presented with STEMI within 12 h of symptom onset. Patients were grouped according to low and high TIMI risk scores. Results: We enrolled 390 patients (mean age 61.9 ±13.6 years; 73% were men). The NLR, platelet distribution width (PDW) and uric acid level (UA) were significantly associated with a high TIMI-STEMI risk score (p = 0.016, p = 0.008, p = 0.030, respectively), but PLR was not associated with a high TIMI-STEMI risk score. Left ventricular ejection fraction was an independent predictor of TIMI-STEMI risk score. A cut-off point of TIMI-STEMI score of > 4 predicted in-hospital mortality (sensitivity 75%, specificity 70%, p Conclusions: Neutrophil to lymphocyte ratio, PDW and UA level are convenient, inexpensive and reproducible biomarkers for STEMI prognosis before primary angioplasty when these indicators are combined with the TIMI-STEMI risk score. We believe that these significant findings can guide further clinical practice.
机译：简介：心肌梗塞溶栓（TIMI）风险评分的计算方法是ST抬高急性心肌梗死（STEMI）死亡率和缺血事件的独立预测因子之和。多项研究表明，嗜中性白细胞与淋巴细胞的比率（NLR）是一种预后的炎症指标。在初步研究中，血小板与淋巴细胞的比率（PLR）已被提议作为血栓形成前的标志物。从未研究过STEMI的NLR，PLR和TIMI风险评分之间的关​​系。目的：评估TIMI-STEMI风险评分与STEMI中NLR，PLR和其他生化指标之间的关联。材料和方法：在这项回顾性研究中，我们评估了390名在症状发作12小时内出现STEMI的患者。根据TIMI风险评分的高低对患者进行分组。结果：我们招募了390名患者（平均年龄61.9±13.6岁;男性占73％）。 NLR，血小板分布宽度（PDW）和尿酸水平（UA）与较高的TIMI-STEMI风险评分显着相关（分别为p = 0.016，p = 0.008，p = 0.030），但PLR与血脂水平无关TIMI-STEMI风险评分高。左心室射血分数是TIMI-STEMI危险评分的独立预测因子。 TIMI-STEMI评分的临界点> 4预测的院内死亡率（敏感性75％，特异性70％，p）结论：中性粒细胞与淋巴细胞的比率，PDW和UA水平是STEMI预后的便捷，廉价且可重现的生物标志物当这些指标与TIMI-STEMI风险评分结合使用时，我们将对这些患者进行原发性血管成形术。

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