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首页> 外文期刊>Advances in Surgical Sciences >Postoperative Use of Antibiotics in Adults with Non-perforated Appendicitis Subjected to Open Appendectomy
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Postoperative Use of Antibiotics in Adults with Non-perforated Appendicitis Subjected to Open Appendectomy

机译：成人开孔阑尾切除术术后非穿孔性阑尾炎术后的抗生素使用

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Acute appendicitis is the most common cause of acute abdominal pain necessitating appendicectomy. The aim of this study was to determine the role of postoperative antibiotics in non-perforated appendicitis regarding; superficial site infections (SSIs), deep site infections (DSIs), complications and the length of hospital stay. This prospective study was carried out on 112 patients diagnosed as acute appendicitis at the Emergency Hospital, General Surgery Department, Tanta University Hospital from March 2014 to April 2016. The patients classified into two groups: Group 1: patients who received postoperative antibiotics, these included 55 patients and Group 2: patients who did not receive postoperative antibiotics and these included 57 patients. The patients subjected to open appendectomy through a standard Grid-Iron incision. The patients' characteristics, ultrasound findings, antibiotics regimen, operative diagnosis, length of hospital stay, wound infection, complications and histopathological findings were analysed using SPSS V 20. Out of 112 patients, 72 patients were male and 40 patients were female. The patients' age ranged from 18 to 55 years with a mean age of 26 years. There is no significant difference regarding patient's age, sex, medical comorbidities, fever, radiologic findings or operative time between the two groups. Treatment with postoperative antibiotics did not significantly reduce the risk of developing superficial SSIs, DSIs. The patients received postoperative antibiotics were significantly more likely to sustain urinary tract infection (P=0.03) a postoperative diarrhea (P = 0.02), increased risk of Clostridium difficile infection (P =0.01) with higher rates of both readmission (P= 0.08) and reoperation (P = 0.07) with a significantly longer hospital stay (2.6 vs 1.4 days, P = 0.001). The use of postoperative antibiotic treatment for nonperforated appendicitis did not reduce the infectious complications while increasing postoperative morbidity and increase the length of hospital stay.
机译：急性阑尾炎是需要进行阑尾切除术的急性腹痛的最常见原因。这项研究的目的是确定术后抗生素在非穿孔性阑尾炎中的作用;浅表部位感染（SSI），深部部位感染（DSI），并发症和住院时间。这项前瞻性研究于2014年3月至2016年4月在坦塔大学医院普通外科急诊医院对112例被诊断为急性阑尾炎的患者进行了研究。患者分为两组：第1组：术后接受抗生素治疗的患者，包括55例患者和第2组：未接受术后抗生素治疗的患者，其中包括57例患者。患者通过标准的Grid-Iron切口进行开放性阑尾切除术。使用SPSS V 20分析患者的特征，超声检查结果，抗生素治疗方案，手术诊断，住院时间，伤口感染，并发症和组织病理学结果。在112例患者中，男性72例，女性40例。患者年龄为18至55岁，平均年龄为26岁。两组患者的年龄，性别，合并症，发烧，影像学表现或手术时间无明显差异。术后用抗生素治疗并不能显着降低发生浅表性SSI，DSI的风险。术后接受抗生素治疗的患者出现尿道感染的可能性更高（P = 0.03），腹泻的可能性更高（P = 0.02），艰难梭菌感染的风险增加（P = 0.01），两种再入院率更高（P = 0.08）。再次手术（P = 0.07），住院时间明显延长（2.6 vs 1.4天，P = 0.001）。术后抗生素治疗非穿孔性阑尾炎并没有减少感染并发症，同时增加了术后发病率并延长了住院时间。

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