• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>African Journal of Biotechnology >Protective and therapeutic effects of Chamomilla Recutita extract on subacute ethanol intoxication in white albino rats
【24h】

Protective and therapeutic effects of Chamomilla Recutita extract on subacute ethanol intoxication in white albino rats

机译：白mo提取物对白化白鼠亚急性乙醇中毒的保护作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Medicinal plants may provide an effective remedy for the enormous health burden posed by alcohol abuse. The aim of this study was to?investigate putative protective and therapeutic effects of an aqueous extract of?Chamomilla recutita?(CHR) on alcohol-induced hepato-nephrotoxicity and pancytopenia in rats. Rats fed only alcohol developed hepato-nephrotoxicity as indicated by significant increases in the levels of all hepatic enzyme markers [alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GTT)], significantly decreased levels of total protein and increased levels of serum creatinine and urea. Ethanol administered rats also developed pancytopeniawithdecreased levels of total red blood cells (RBC's), white blood cells (WBC's) and platelets and macrocytic, hypochromic anemia. Oral administration of CHR extract for 28 days to normal rats confirmed its safe use with all the above biochemical and hematological parameters remaining within their normal levels. Pre-treatment or post-treatment with CHR to ethanol administered rats ameliorated the deleterious effects of ethanol on all biochemical and hematological parameters. CHR effect was more potent in pretreated- than in post-treated group. The results also show that a diminution of oxidative stress is one mechanism by which CHR extract exerts potent protective and mild therapeutic effects against alcohol-induced hepato-nephrotoxicity and pancytopenia.
机译：药用植物可以为酗酒带来的巨大健康负担提供有效的补救措施。这项研究的目的是为了研究“ Chamomilla recutita”（CHR）的水提取物对酒精诱导的大鼠肝肾毒性和全血细胞减少症的保护性和治疗作用。所有肝酶标记物[丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），碱性磷酸酶（ALP）和γ-谷氨酰转移酶（GTT）的水平均显着升高，表明仅饮酒的大鼠会出现肝肾毒性。 ，总蛋白水平明显降低，血清肌酐和尿素水平升高。接受乙醇治疗的大鼠还发生了全血细胞减少症，总红细胞（RBC），白细胞（WBC）和血小板水平降低，巨噬细胞，低色素性贫血。对正常大鼠口服CHR提取物28天证实了其安全使用，并且上述所有生化和血液学参数均保持在正常水平内。对给予乙醇的大鼠进行CHR预处理或后处理可改善乙醇对所有生化和血液学参数的有害影响。预处理组的CHR效果比后处理组更有效。结果还表明，减少氧化应激是CHR提取物对酒精诱导的肝肾毒性和全血细胞减少症发挥有效保护作用和温和治疗作用的一种机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号