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首页> 外文期刊>African Journal of Biotechnology >Anti-toxoplasma gondii activity of constituents from Balsamocitrus camerunensis L (Rutaceae)
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Anti-toxoplasma gondii activity of constituents from Balsamocitrus camerunensis L (Rutaceae)

机译：香脂苦瓜（芸香科）各成分的弓形虫活性

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摘要

Isolation, characterization and anti-Toxoplasma gondii activity of constituents from the CH2Cl2/MeOH (1/1) extract of the roots of the cameroonian plant Balsamocitrus camerunensis L. were investigated in this study. Four known coumarins derivatives were isolated, namely, marmin (1), imperatorin (2), xanthoxyletin (3), 6,7-Dimethoxycoumarin (4) and an acridone derivative namely 1-hydroxy-3-methoxy-acridone (5). Their structures were established on the basis of their spectroscopic data compared to reported results. Some of the isolated compounds showed noteworthy activity against Toxoplasma gondii intracellular parasite in mammals with an inhibition of parasite growth of around 46.44% for compound 4 and 82.12% for compound 3 which was the most active compound.
机译：本研究研究了喀麦隆植物香脂Balsamocitrus camerunensis L.根的CH2Cl2 / MeOH（1/1）提取物的组成成分的分离，表征和抗弓形虫活性。分离出四种已知的香豆素衍生物，即马明（1），欧前胡素（2），黄酮素（3），6,7-二甲氧基香豆素（4）和a啶酮衍生物即1-羟基-3-甲氧基-啶酮（5）。它们的结构是根据其光谱数据与报告的结果进行比较而确定的。一些分离的化合物在哺乳动物中显示出对弓形虫胞内寄生虫的显着活性，其中对化合物4的寄生虫生长的抑制作用约为46.44％，对于活性最高的化合物3的抑制率为82.12％。

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