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首页> 外文期刊>African Journal of Biotechnology >Bauhinia purpurea leaves extracts exhibited in vitro antiproliferative and antioxidant activities
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Bauhinia purpurea leaves extracts exhibited in vitro antiproliferative and antioxidant activities

机译：紫荆叶提取物具有体外抗增殖和抗氧化活性

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The antiproliferative and antioxidant activities of various extracts of the leaves ofBauhinia purpurea?were studied using?in vitro?standard assays. The aqueous and chloroform extracts successfully inhibited the proliferation of all cancer cells while the methanol extract inhibited the proliferation of all cells except the CEMss cells when assessed using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. The aqueous extract was effective against MCF-7 (IC50?≈ 9μg/ml), MDA-MB 231 (IC50?≈?17 μg/ml) and?Caov-3 (IC50?≈ 16?μg/ml); the chloroform extract was highly effective against the CEMss (IC50?≈ 18?μg/ml)?and HeLa (IC50?≈ 21?μg/ml); and the methanol extract was highly effective only against the HL-60 (≈ 12?μg/ml)?cell lines.?Interestingly, all extracts did not inhibit the proliferation of 3T3 cells suggesting their non-cytotoxic properties. The aqueous and methanol, but not chloroform, extracts of?B. purpurea?(20, 100 and 500?mg/ml) exhibited concentration-dependent antioxidant activity only in the superoxide scavenging assay, but low to moderate activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, which could be associated with their total phenolic contents. In conclusion, the?B. purpurea?leaf possesses potential antiproliferative and concentration-dependent?antioxidant activities. Purification and determination of active compounds are required for further study.
机译：紫茎泽兰叶片的各种提取物的抗增殖和抗氧化活性均采用“体外”标准方法进行了研究。当使用3，（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓评估时，水提取物和氯仿提取物成功抑制了所有癌细胞的增殖，而甲醇提取物抑制了除CEMss细胞以外的所有细胞的增殖。溴化物（MTT）分析。该水提取物对MCF-7（IC50≤≈9μg/ ml），MDA-MB 231（IC50≤≈17μg/ ml）和αCaov-3（IC50≤≈16μg/ ml）有效。氯仿提取物对CEMss（IC50≤18μg/ ml）和HeLa（IC50≤21μg/ ml）非常有效。甲醇提取物仅对HL-60（≈12？μg/ ml）？细胞系有效。？有趣的是，所有提取物均未抑制3T3细胞的增殖，表明其无细胞毒性。 βB的水溶液和甲醇而不是氯仿。 purpurea？（20、100和500？mg / ml）仅在超氧化物清除试验中表现出浓度依赖性的抗氧化活性，而在2,2-二苯基-1-picylhydrazyl（DPPH）自由基清除试验中具有低至中等的活性。可能与它们的总酚含量有关。总之，B。紫叶叶具有潜在的抗增殖和浓度依赖性抗氧化活性。活性化合物的纯化和测定需要进一步研究。

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