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首页> 外文期刊>African Journal of Biotechnology >The in vivo effect of N-nitrosomorpholine on the activity of enzymes in rat blood serums and liver
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The in vivo effect of N-nitrosomorpholine on the activity of enzymes in rat blood serums and liver

机译：N-亚硝基吗啉对大鼠血清和肝脏中酶活性的体内作用

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Neoplasm antigens outnumber the enzymes which are utilized to determine the cancer. Cancer development in the living organisms chronologically follows the cytotoxic, organotoxic and mutagenic alterations. Generally, the first symptom for chemical carcinogens is a metabolical response in connection with the detoxification phenomenon and for the infective agents the first symptom is often an immune response. Many nitrosamines similar to N-nitrosomorpholine have been considered as carcinogens. The cancerogenic effect of N-nitrosomorpholine (NMOR) on different animal species has been confirmed experimentally. The aim was to analyse the acute toxic effect of the N-nitrosomorpholine on the?Rattus norvegicus?race rats in this study. The administration of N-nitrosomorpholine causes alteration of some enzymes. The enzyme activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were determined for all the samples of blood serum and liver tissue. The results demonstrated that there was an increase in the levels of the ALP, ALT, AST and LDH enzyme activities regarding to the?in vivo?effect of the N-nitrosomorpholine and the increases were evaluated as the metabolic response of liver to hepatotoxic action. NMOR results in the modifications on the biological macromolecules owing to its alkylating characteristic. The degradation and turn over of the protein gains speed gradually till alkylating factor disappear. This case in the circulation appears as the increase of the enzyme activity. These alterations are responsible for carcinogenicity and happen as liver cancer observation in the liver.
机译：肿瘤抗原数量超过用来确定癌症的酶。生命有机体中的癌症发展按时间顺序遵循细胞毒性，有机毒性和诱变改变。通常，化学致癌物的第一症状是与排毒现象有关的代谢反应，而对于传染剂，第一症状通常是免疫反应。许多类似于N-亚硝基吗啉的亚硝胺被认为是致癌物。 N-亚硝基吗啉（NMOR）对不同动物物种的致癌作用已通过实验证实。目的是分析本研究中N-亚硝基吗啉对北R大鼠的急性毒性作用。 N-亚硝基吗啉的施用引起某些酶的改变。测定所有血清和肝组织样品的丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），碱性磷酸酶（ALP）和乳酸脱氢酶（LDH）的酶活性。结果表明，关于N-亚硝基吗啉的体内作用，ALP，ALT，AST和LDH酶活性水平增加，并且该增加被评估为肝脏对肝毒性作用的代谢反应。 NMOR由于其烷基化特性而导致生物大分子的修饰。蛋白质的降解和周转逐渐加快，直到烷基化因子消失。循环中的这种情况表现为酶活性的增加。这些改变与致癌性有关，并在肝脏中观察到肝癌。

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