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首页> 外文期刊>African Journal of Biotechnology >Effect of methanolic extract of Dennettia tripetala (pepper fruit) on biomarkers of oxidative stress and lipid peroxidation in type 2 diabetic male wistar rats
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Effect of methanolic extract of Dennettia tripetala (pepper fruit) on biomarkers of oxidative stress and lipid peroxidation in type 2 diabetic male wistar rats

机译：牛膝草提取物对2型糖尿病雄性Wistar大鼠氧化应激和脂质过氧化生物标志物的影响

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Oxidative stress resulting from chronic hyperglycemia in diabetes is due to high production of reactive oxygen species and/or a decrease in the antioxidant defense system activity. The study was designed to investigate the ameliorative effect of methanolic extract of Dennettia tripetala (DT) on oxidative stress and blood glucose level in type II diabetic male Wistar rats. Type II diabetes was induced by a single intraperitoneal injection of streptozotocin (40 mg/kg) after 2 weeks of 10% fructose diet. Twenty-five (25) rats were randomly divided into five groups, namely: 1 (normal control), 2 (negative control), 3 (10 mg/kg of glibenclamide), 4 (100 mg/kg of DT extract) and 5 (200 mg/kg of DT extract). The administration of the extract caused a significant decrease in blood glucose levels in all treatment groups. A significant (P<0.01) decrease in malonaldehyde (MDA) activity was observed in the group treated with 100 and 200 mg/kg of DT extract compared to diabetic control. Catalase (CAT) activity showed a significant (P<0.05) increase in the group treated with 200 mg/kg of DT extract compared to the normal control. However, the extract did not affect GSH-Px, SOD and CAT activities. The findings suggest ameliorative effect of DT extract in diabetic Wistar rats.
机译：由糖尿病的慢性高血糖症引起的氧化应激是由于活性氧种类的大量产生和/或抗氧化剂防御系统活性的降低。这项研究旨在调查三叶草（Dennettiatripetala）（DT）甲醇提取物对II型糖尿病雄性Wistar大鼠氧化应激和血糖水平的改善作用。在10％果糖饮食2周后，一次腹膜内注射链脲佐菌素（40 mg / kg）可诱发II型糖尿病。二十五（25）只大鼠随机分为五组，分别为：1（正常对照组），2（阴性对照组），3（10 mg / kg格列本脲），4（100 mg / kg DT提取物）和5 （200 mg / kg DT提取物）。提取物的施用导致所有治疗组的血糖水平显着降低。与糖尿病对照组相比，在用100和200 mg / kg DT提取物治疗的组中，丙二醛（MDA）活性显着降低（P <0.01）。与正常对照组相比，用200 mg / kg DT提取物处理的组中的过氧化氢酶（CAT）活性显示出显着（P <0.05）增加。但是，提取物不影响GSH-Px，SOD和CAT活性。这些发现暗示了DT提取物对糖尿病Wistar大鼠的改善作用。

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