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首页> 外文期刊>African Journal of Biotechnology >Protective role of melatonin on blood parameters following irradiation in rat
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Protective role of melatonin on blood parameters following irradiation in rat

机译：褪黑素对大鼠辐射后血液参数的保护作用

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The aim of this study was to determine the preventive role of melatonin on several blood parameters after irradiation exposure in rats. A total of 100 adult Wistar albino rats were divided into five groups. One group was used as control and other groups were treated with 60, 90, 120 and 160 cGy/min of radiation, respectively. A dose of 4 mg/kg of melatonin was administered subcutaneously to 10 rats from each group exposed to different amounts of radiation. Saline was administered to 10 rats from the control group. 20 days after the completion of the 10-day experiment, the rats were sacrificed and blood samples were collected for determination of erythrocytes, leukocytes, hemoglobin, hematocrit and thrombocyte levels. In the group that received 60 cGy-radiation, the number of erythrocytes were similar to the control group, whereas the leukocyte and thrombocyte counts were increased. In the 90 cGy-radiation exposed rats, erythrocytes, hemoglobin and hematocrit values were low as compared to the controls. In the 120 to 160 cGy-radiation treated rats, leukocyte, hemoglobin, hematocrit and thrombocyte numbers were significantly different from the control groups (P<0.01). In the radiation-melatonin administrated rats, no difference was seen in the blood parameters as compared to the control group, except for the thrombocyte numbers. The thrombocyte numbers in all experimental groups were significantly higher than the controls (P<0.05). Melatonin was effective to reverse the deleterious effects of radiation on the blood parameters in rats and this effect was found to be dose-dependent.
机译：这项研究的目的是确定褪黑素对大鼠辐射后几种血液参数的预防作用。将总共​​100只成年Wistar白化病大鼠分成五组。一组用作对照组，其他组分别接受60、90、120和160 cGy / min的放射线治疗。对每组暴露于不同辐射量的10只大鼠皮下给予4 mg / kg褪黑激素剂量。向对照组的10只大鼠施用盐水。在为期10天的实验完成后20天，处死大鼠并收集血样以确定红细胞，白细胞，血红蛋白，血细胞比容和血小板水平。在接受60 cGy辐射的组中，红细胞数量与对照组相似，而白细胞和血小板计数增加。在暴露于90 cGy辐射的大鼠中，与对照组相比，红细胞，血红蛋白和血细胞比容值较低。在120至160 cGy辐射治疗的大鼠中，白细胞，血红蛋白，血细胞比容和血小板数量与对照组相比有显着差异（P <0.01）。在放射褪黑激素给药的大鼠中，除了血小板数量外，与对照组相比，血液参数没有差异。所有实验组的血小板数均显着高于对照组（P <0.05）。褪黑素可有效逆转辐射对大鼠血液参数的有害影响，并且发现这种影响是剂量依赖性的。

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