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首页> 外文期刊>African Journal of Biotechnology >Anti-inflammatory and analgesic activity of the methanol extract of Malva parviflora Linn (Malvaceae) in rats
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Anti-inflammatory and analgesic activity of the methanol extract of Malva parviflora Linn (Malvaceae) in rats

机译：小花锦葵甲醇提取物的抗炎和镇痛作用

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Malva parviflora?Linn Malvaceae is a medicinal plant used for the treatment of wounds and other related ailments by the Xhosa people of South Africa. The anti-inflammatory activity of the stem extract of this plant was assessed using carrageenan-induced paw oedema and histamine-induced paw oedema. The analgesic effect was determined using the acetic acid writhing method as well as formalin test. The extract at 100 and 200 mgkg-1?body weight reduced significantly, the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract showed a good analgesic effect characterized by reduction in the number of writhes when compared to the control. The extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin, signifying its analgesic effect. These results were also comparable to those of indomethacin, the reference drug used in this study. Since the plant extract reduced significantly the formation of oedema induced by carrageenan and histamine as well as reduced the number of writhes in acetic acid-induced writhing models and dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin, it is concluded that the use ofM.?parviflora?for the treatment of inflammed purulent wounds, swellings, bruises and broken limbs may have been justified.
机译：锦葵（Lin Malvaceae）是一种药用植物，用于治疗南非科萨人的伤口和其他相关疾病。使用角叉菜胶诱导的爪水肿和组胺诱导的爪水肿评估该植物茎提取物的抗炎活性。使用乙酸扭体法和福尔马林试验确定镇痛效果。提取物在100和200 mgkg-1？体重下明显减少，由角叉菜胶和组胺引起的水肿形成。在乙酸诱导的扭体模型中，与对照相比，提取物显示出良好的镇痛作用，其特征在于减少了打针次数。该提取物在注射2.5％福尔马林的大鼠中引起舔time时间和舔frequency频率的剂量依赖性降低，表明其镇痛作用。这些结果也与吲哚美辛（本研究中使用的参考药物）的结果相当。由于植物提取物显着减少了由角叉菜胶和组胺引起的水肿的形成，并且减少了乙酸诱发的扭体模型中的扭曲次数，并且剂量依赖性地降低了注射2.5％福尔马林的大鼠的舔ing时间和舔frequency频率，因此结论是，使用小枝摩根氏菌治疗发炎的化脓性伤口，肿胀，瘀伤和四肢骨折可能是合理的。

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