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首页> 外文期刊>African Journal of Biotechnology >Semi-quantitative analysis of endometrial receptivity marker mRNA expression in the mid-secretory endometrium of patients with uterine fibromas
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Semi-quantitative analysis of endometrial receptivity marker mRNA expression in the mid-secretory endometrium of patients with uterine fibromas

机译：子宫纤维瘤患者分泌物中子宫内膜子宫内膜接受标志物mRNA表达的半定量分析

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摘要

In fertile women, expression of molecular marker of endometrial receptivity,?HOXA11, leukemia inhibitory factor (LIF) and basic transcriptional element binding protein 1 (BTEB1),?rises during the luteal phase with the peak occurring during the implantation window. We evaluated the transcript levels of HOXA-11, LIF and BTEB1 in the mid-secretory endometrium of infertile patients with uterine fibroid infertility (n = 8) and from normal fertile women (n = 8).?Expression levels of HOXA11, LIF and BTEB1 mRNA were measured in endometrium during the mid-secretory phase using semi-quantitative?reverse transcriptase-polymerase chain reaction (RT-PCR).?Endometrial HOXA11, LIF and BTEB1 mRNA expression levels (normalized to ?-actin expression) were significantly decreased in endometrium of infertile patients with uterine fibroid as compared with healthy fertile controls at the time of implantation (P<0.05).?The results suggest that the alteration in expression pattern of some genes could account for some aspects of infertility in patients with uterine fibroma.
机译：在可育妇女中，子宫内膜接受性分子标志物HOXA11，白血病抑制因子（LIF）和碱性转录元件结合蛋白1（BTEB1）的表达在黄体期上升，并在植入窗口期出现高峰。我们评估了子宫肌瘤不育症不孕患者（n = 8）和正常受孕妇女（n = 8）的分泌中期子宫内膜中HOXA-11，LIF和BTEB1的转录水平。HOXA11，LIF和使用半定量逆转录聚合酶链反应（RT-PCR）在分泌中期对子宫内膜BTEB1 mRNA进行检测。子宫内膜HOXA11，LIF和BTEB1 mRNA表达水平（标准化为β-actin表达）显着降低与健康受精者在植入时子宫肌瘤患者子宫内膜异位的比较（P <0.05）。结果表明，某些基因表达模式的改变可以解释子宫肌瘤患者不孕的某些方面。

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