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首页> 外文期刊>African Journal of Biotechnology >Ginger-supplemented diet ameliorates ammonium nitrate-induced oxidative stress in rats
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Ginger-supplemented diet ameliorates ammonium nitrate-induced oxidative stress in rats

机译：生姜补充饮食可改善硝酸铵诱导的大鼠氧化应激

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The present study was designed to evaluate the capacity of ginger to repair the oxidative stress induced by ammonium nitrate.?50 male rats were divided into 5 groups; they underwent an oral treatment of ammonium nitrate and/or ginger (N mg/kg body weight + G% in diet) during 30 days. Group I served as control (C); group II (G) received a diet with 2% of ginger; group III (N) received a toxic dose of ammonium nitrate and normal diet; group IV (NG) received a toxic dose of ammonium nitrate and a diet containing 2% ginger and group V (N+G) received a?highly toxic?dose?of ammonium nitrate and an experimental diet containing 2% ginger. The treatment by ammonium nitrate was found to elicit a rise in blood biochemical parameters, a disorder in hematological parameters and significant decrease in the tissue glutathione level. Feeding ginger supplemented diets to ammonium nitrate treated rats restored all the parameters studied compared to the controls. These findings suggest that ginger treatment exerts a protective effect on metabolic disorders by decreasing oxidative stress.
机译：本研究旨在评估姜修复硝酸铵诱导的氧化应激的能力。将50只雄性大鼠分为5组;每组5只。他们在30天内接受了硝酸铵和/或生姜的口服治疗（N mg / kg体重+饮食中的G％）。第一组作为对照组（C）;第二组（G）的饮食中含2％的生姜;第三组（N）接受有毒剂量的硝酸铵和正常饮食;第四组（NG）接受中毒剂量的硝酸铵和含2％生姜的饮食，第五组（N + G）接受“高毒性剂量”的硝酸铵和实验含2％生姜的饮食。发现用硝酸铵进行治疗会引起血液生化指标的升高，血液学参数的紊乱以及组织谷胱甘肽水平的显着降低。与对照相比，向硝酸铵处理的大鼠饲喂生姜补充饮食可恢复所有研究参数。这些发现表明，生姜治疗可通过降低氧化应激对代谢紊乱起到保护作用。

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