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首页> 外文期刊>African Journal of Biotechnology >Effects of a novel recombinant somatostatin DNA vaccination on rat fertility and offspring growth
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Effects of a novel recombinant somatostatin DNA vaccination on rat fertility and offspring growth

机译：新型重组生长抑素DNA疫苗接种对大鼠生育力和后代生长的影响

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摘要

In this study, we investigated the immune effects of a novel somatostatin (SS) DNA vaccine—pVAX-asd-GS/2SS (pGS/2SS), administrated with intramuscular (IM) and subcutaneous (SC) two delivery routes on female rat fertility and offspring growth. Results show that this pGS/2SS DNA vaccine could induce effective anti-SS immune response in rats (IM group and SC group). The antibody peak of female rats in IM group occurred later than that in SC group (12th week vs. 10th week), but higher than that in SC group (OD=1.122±0.273 vs. OD=0.614±0.183). Immunized groups had higher pregnancy rate, litter size, birth weight of pup and weight gain of pup than the control group (P<0.05). Compared to SC immunization, IM immunization had better improvement in the pregnancy rate of dam and the weight gain of pup (P<0.05). However, in litter sizes and birth weight of pups, SC immunization was better than IM immunization. In conclusion, pGS/2SS as a powerful DNA vaccine improves the fertility of female rats and the growth of pups.
机译：在这项研究中，我们研究了一种新型生长抑素（SS）DNA疫苗-pVAX-asd-GS / 2SS（pGS / 2SS），肌内（IM）和皮下（SC）两种给药途径对雌性大鼠生育力的免疫作用和后代的成长。结果表明，该pGS / 2SS DNA疫苗可以诱导大鼠（IM组和SC组）有效的抗SS免疫反应。 IM组的雌性大鼠的抗体峰出现时间比SC组晚（第12周vs.第10周），但高于SC组（OD = 1.122±0.273 vs.OD = 0.614±0.183）。免疫组的妊娠率，产仔数，幼仔的出生体重和幼仔的体重增加均高于对照组（P <0.05）。与SC免疫相比，IM免疫对大坝的怀孕率和幼犬体重增加有更好的改善（P <0.05）。但是，在幼仔大小和出生体重方面，SC免疫优于IM免疫。总之，pGS / 2SS作为一种强大的DNA疫苗，可以改善雌性大鼠的生育能力和幼仔的生长。

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