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首页> 外文期刊>Vaccine >Effect of genetic adjuvants on immune respondance, growth and hormone levels in somatostatin DNA vaccination-induced Hu lambs.
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Effect of genetic adjuvants on immune respondance, growth and hormone levels in somatostatin DNA vaccination-induced Hu lambs.

机译：遗传佐剂对生长抑素DNA疫苗接种的Hu羔羊免疫应答，生长和激素水平的影响。

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摘要

The aim of current study was to evaluate the prospects of adjuvants against DNA vaccination (pES/2SS) encoding somatostatin (SS) and hepatitis B surface antigen fusion gene. A total of 60 female Hu lambs were divided into 6 groups and vaccinated in the context of various adjuvants (and controls): pE-CpG, Escherichia coli DH5 alpha DNA, crude liposomes or GM-CSF in combination with the pES/2SS plasmid. Controls included pES/2SS only vaccinated and physiological saline groups. The antibody against SS level in the E. coli DH5 alpha DNA group was significantly increased compared to that in the pES/2SS vaccine alone. Vaccination with pES/2SS/pE-CpG or pES/2SS/E. coli DH5 alpha resulted in elevated weight gains that were 33.0 and 31.6% higher, respectively, than in saline group and pES/2SS only vaccinated controls. The concentrations of GH and IGF-I in the DNA vaccine groups were remarkably higher than those in the saline group, and those with positive antibody higher than negative antibody. These results suggested that different adjuvant/pES/2SS combinations can enhance the immune effect and had significant positive effects on growth.
机译：当前研究的目的是评估佐剂抗编码生长抑素（SS）和乙型肝炎表面抗原融合基因的DNA疫苗（pES / 2SS）的前景。将总共​​60只雌性Hu羔羊分为6组，并在各种佐剂（和对照）的背景下接种：pE-CpG，大肠杆菌DH5αDNA，粗脂质体或GM-CSF pES / 2SS质粒。对照包括仅接种了pES / 2SS的疫苗组和生理盐水组。 E中针对SS水平的抗体。与单独的pES / 2SS疫苗相比，大肠杆菌DH5αDNA组明显增加。用pES / 2SS / pE-CpG或pES / 2SS / iE接种。大肠杆菌DH5α导致体重增加，分别比生理盐水组和仅接种了pES / 2SS的对照组高33.0和31.6％。 DNA疫苗组中GH和IGF-I的浓度显着高于生理盐水组，阳性抗体的浓度高于阴性抗体。这些结果表明，不同的佐剂/ pES / 2SS组合可以增强免疫效果，并对生长具有显着的积极作用。

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