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首页> 外文期刊>African Journal of Biotechnology >Haptoglobin gene polymorphism influences the effect of malaria infection on host haptoglobin plasma level but not susceptibility to the disease
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Haptoglobin gene polymorphism influences the effect of malaria infection on host haptoglobin plasma level but not susceptibility to the disease

机译：肝珠蛋白基因多态性影响疟疾感染对宿主触珠蛋白血浆水平的影响，但不影响疾病易感性

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A cohort of 344 children aged less than five years were followed for one year to establish the relationship between haptoglobin genotype, haptoglobin plasma level and malaria infection and susceptibility. Haptoglobin genotyping was undertaken using PCR, with plasma haptoglobin levels measured using indirect ELISA. The number of children carrying the genotypes Hp1-1, Hp1-2?and Hp2-2?were 85, 171 and 88, respectively. The state of malaria infection was assessed using standard microscopy method to detect parasitemia. Higher plasma haptoglobin level tended to be associated with negative parasitemia (P=0.01). During malaria infection, haptoglobin level decreased in all individuals and, the decrease significantly varied by genotype, whereby the decrease was greater in Hp2-2?individuals than the other genotypes. A longitudinal examination of blood smears revealed a slightly higher proportion of children carrying the Hp2-2?genotype (12.4%) to be positive for malaria, as compared to children with the genotype Hp1-1?(11.7%) and Hp1-2?(11.6%). The present study has demonstrated that malaria infection in children affects the haptoglobin plasma level and the effect is influenced by haptoglobin genotype. The study has also revealed a limited influence of haptoglobin genotype to malaria infection and disease development.
机译：研究人员对344名年龄小于5岁的儿童进行了为期一年的研究，以建立触珠蛋白基因型，触珠蛋白血浆水平与疟疾感染和易感性之间的关系。使用PCR进行肝珠蛋白基因分型，使用间接ELISA测量血浆触珠蛋白水平。携带Hp1-1，Hp1-2？和Hp2-2？基因型的儿童人数分别为85、171和88。使用标准显微镜方法评估疟疾感染状况以检测寄生虫病。血浆触珠蛋白水平升高往往与阴性寄生虫血症相关（P = 0.01）。在疟疾感染期间，触珠蛋​​白水平在所有个体中均下降，并且该下降因基因型而有显着差异，因此，Hp2-2个体的下降幅度大于其他基因型。对血涂片的纵向检查显示，携带Hp2-2？基因型的儿童中疟疾呈阳性的比例略高于具有Hp1-1？基因型的儿童（11.7％）和具有Hp1-2？基因型的儿童。 （11.6％）。本研究表明，儿童疟疾感染会影响触珠蛋白血浆水平，并且该影响受触珠蛋白基因型的影响。该研究还揭示了触珠蛋白基因型对疟疾感染和疾病发展的影响有限。

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