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首页> 外文期刊>African Journal of Biotechnology >In vitro anthelmintic effects of crude aqueous extracts of Tephrosia vogelii, Tephrosia villosa and Carica papaya leaves and seeds
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In vitro anthelmintic effects of crude aqueous extracts of Tephrosia vogelii, Tephrosia villosa and Carica papaya leaves and seeds

机译：伏地黄，毛地黄和番木瓜叶和种子的粗水提物的体外驱虫作用

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The prevalence of anthelmintic resistance and the consumer demand for alternative farming systems that limit the use of chemical anthelmintics has made the search for alternative gastrointestinal nematode parasites control methods crucial. Traditional medicinal/herbal plants can offer an alternative to the reliance on chemical anthelmintic drugs. This study evaluates the efficacy of crude aqueous extracts of Tephrosia vogelii Hook., Tephrosia villosa Pers., and Carica papaya Linn. leaves and Carica papaya Linn. seeds against gastrointestinal nematodes using in vitro egg hatch and larval development inhibition assays. Rectal faecal samples from sheep were subjected to parasitological examination for faecal egg counts (FEC) using the McMaster counting technique. 100 g of dried and poultice aqueous leaf extract of T. vogelii, T. villosa, C. papaya leaves and seeds was blended into liquefaction in 200 ml of distilled water then boiled at 90-100°C for 1 h and cooled. Levamisol and distilled water were used as positive and negative control in the bioassay. Egg hatch assay revealed more than 95.8% reduction in egg hatch at concentration of 500 mg/ml for dried and poultice paste of T. vogelii leaves and C. papaya seeds. Larval development inhibition assay results showed that both dried and poultice paste of T. vogelii leaves and C. papaya seeds extract yielded more than 98% inhibition at a concentration of 500 mg/ml. Based on the LD50 dried extract of C. papaya seeds was most potent extracts for the inhibition of both egg hatching (49.94 mg/ml) and larval development (49.32 mg/ml). Both poultice and dried extract for all the plants showed significant and dose dependent egg and larval development inhibition. These findings indicate that the evaluated plants have potential anthelmintic effect and could provide viable alternatives for the control of gastrointestinal helminthes in ruminants.
机译：驱虫药耐药性的普遍存在以及消费者对限制化学驱虫药使用的替代耕作系统的需求，使得寻找替代的胃肠道线虫寄生虫控制方法变得至关重要。传统的药用/草药植物可以替代对化学驱虫药的依赖。这项研究评估了Tephrosia vogelii Hook。，Tephrosia villosa Pers。和Carica木瓜Linn的粗制水提物的功效。叶和番木瓜Linn。种子通过体外卵孵化和幼虫发育抑制试验抗胃肠道线虫。使用McMaster计数技术对绵羊的直肠粪便样本进行了寄生虫学检查，以检测粪便卵数（FEC）。将100克干燥的和粉状的T. vogelii，T。villosa，C。番木瓜叶和种子的叶子提取物在200 ml蒸馏水中混合成液化，然后在90-100°C下煮沸1 h并冷却。左旋咪唑和蒸馏水在生物测定中用作阳性和阴性对照。卵孵化试验表明，对于500mg / ml伏氏锥虫叶和番木瓜种子的干燥糊剂和糊剂糊，卵孵化率可降低95.8％以上。幼虫发育抑制试验结果表明，在500 mg / ml的浓度下，沃氏锥虫叶子和木瓜种子提取物的干燥和膏状糊剂均产生超过98％的抑制作用。基于LD50，番木瓜种子的干燥提取物是抑制卵孵化（49.94 mg / ml）和幼虫发育（49.32 mg / ml）的最有效提取物。所有植物的膏药和干提取物均显示出显着且剂量依赖性的卵和幼虫发育抑制。这些发现表明，所评价的植物具有潜在的驱虫作用，并且可以为反刍动物中胃肠道蠕虫的控制提供可行的替代方法。

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