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首页> 外文期刊>African Journal of Biotechnology >Evaluation of Curcuma zerumbet (Zingibaraceae) rhizome extracts sub-acute toxicity on Wistar rats
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Evaluation of Curcuma zerumbet (Zingibaraceae) rhizome extracts sub-acute toxicity on Wistar rats

机译：姜黄提取物对Wistar大鼠亚急性毒性的评价

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摘要

Plant extracts have been lately used by the population to treat various types of diseases, and this has been notably encouraged by the World Health Organization (WHO). Curcuma zerumbet (Zingiberaceae) belonging to the family of the Zingiberaceae, is herbaceous, perennial and, utilized by the population to treat gastric disorders. However, data on the subacute toxicity of this species are scarce in the literature. Therefore, the present work aimed to ascertain the subacute toxicity of different doses of the aqueous and hydroalcoholic extracts from C. zerumbet. These extracts were orally administered through gavage in Wistar rats for 28 consecutive days. This study followed the instructions put forth by Guideline 407 (subacute toxicity) of Organization for Economic Cooperation and Development (OECD). In specific pharmacological tests for acute and subacute toxicity in rats, it can be stated that C. zerumbet extracts doses greater than 5 g/kg neither caused mortality nor presented oral toxicity. Therefore, the extracts toxicity parameters analyzed in different doses on the groups of animals have shown no significant difference from those found in the control group. This allows one to conclude C. zerumbet (Zingiberaceae) rhizome aqueous and alcoholic extracts in high doses to harbor very low toxicity within a short time.
机译：近年来，植物提取物已被人们用于治疗各种类型的疾病，世界卫生组织（WHO）特别鼓励这样做。姜科的姜黄（姜黄科）是多年生草本植物，多年生草本，被人们用来治疗胃病。但是，有关该物种亚急性毒性的数据在文献中很少。因此，目前的工作旨在确定不同剂量的蛇形衣藻含水和水醇提取物的亚急性毒性。通过强饲法连续在Wistar大鼠中口服给予这些提取物28天。这项研究遵循了经济合作与发展组织（OECD）准则407（亚急性毒性）的指示。在针对大鼠的急性和亚急性毒性的特定药理试验中，可以指出，大于5 g / kg的蛇形提取物剂量既没有引起死亡，也没有口服毒性。因此，以不同剂量对动物组进行分析的提取物毒性参数与对照组相比没有显着差异。这样一来，人们就可以得出结论，在短时间内就可以得出高剂量的蛇形菊根茎含水和酒精提取物，从而具有极低的毒性。

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