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首页> 外文期刊>African Journal of Biotechnology >Evaluation of the anti-inflammatory properties of the hexane extract of Hydrocotyle bonariensis Comm. Ex Lam. leaves
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Evaluation of the anti-inflammatory properties of the hexane extract of Hydrocotyle bonariensis Comm. Ex Lam. leaves

机译：香附子己烷提取物抗炎特性的评价前林树叶

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This study investigates the anti-inflammatory properties of Hydrocotyle bonariensis Comm. Ex Lam, a medicinal plant used by indigenous traditional healers to manage chronic inflammatory diseases especially rheumatism and arthritis. The hexane extract of H. bonariensis leaves was evaluated for the presence and concentration of phytochemicals. It was subjected to heat-induced albumin denaturation and human red blood cell (HRBC) membrane stabilization assays. The anti-inflammatory properties of the extract were further assessed by employing the formaldehyde induced arthritis animal model assay. The extract was finally subjected to GC/MS analysis for the tentative identification of the phytochemical constituents. Phytochemical analysis of the extract revealed the presence of saponin, phenol, flavonoid, tannin, terpenoid and sterol. This extract showed the ability to inhibit thermally-induced protein denaturation and stabilize HRBC membrane in concentration dependent manner. In the formaldehyde induced arthritis model, the paw measurements of the rats were taken, their hematological parameters were determined, and their liver function tests (aspartate aminotransferase and alanine aminotransferase activities) were also carried out. Results from the animal model indicated that oral administration of the hexane extract of H. bonariensis leaf at a dose of 250 mg/kg body weight had potent anti-inflammatory action. The GC/MS analysis suggested a number of anti-inflammatory compounds in the extract among which were: hexadecanoic acid methyl ester, falcarinol and phytol. Consequently, the tentative identification of phytochemicals with anti-inflammatory activity in H. bonariensis affirms the anti-inflammatory property of the plant and the phytochemicals could serve as lead compounds for designing anti-inflammatory drugs.
机译：这项研究调查了Hydrocotyle bonariensis Comm。的抗炎特性。 Ex Lam是当地传统治疗师用来治疗慢性炎性疾病，尤其是风湿病和关节炎的药用植物。评估了博纳犬叶子的己烷提取物的存在和浓度。对其进行热诱导的白蛋白变性和人红细胞（HRBC）膜稳定化验。通过使用甲醛诱导的关节炎动物模型试验进一步评估提取物的抗炎特性。最后对提取物进行GC / MS分析，以初步鉴定植物化学成分。提取物的植物化学分析表明存在皂苷，苯酚，类黄酮，单宁，萜类和固醇。该提取物显示出抑制热诱导的蛋白质变性并以浓度依赖性方式稳定HRBC膜的能力。在甲醛诱发的关节炎模型中，测量大鼠的脚掌，确定其血液学参数，并进行肝功能测试（天冬氨酸转氨酶和丙氨酸转氨酶活性）。该动物模型的结果表明，口服剂量为250 mg / kg体重的博氏嗜血杆菌叶己烷提取物具有有效的抗炎作用。 GC / MS分析表明提取物中含有多种抗炎化合物，其中包括：十六烷酸甲酯，泛醇和植醇。因此，初步鉴定出具有抗炎活性的植物中的H.bonariensis具有植物的抗炎特性，并且该植物化学物质可以作为设计抗炎药物的先导化合物。

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