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首页> 外文期刊>African Journal of Biotechnology >From HAMLET to XAMLET: The molecular complex selectively induces cancer cell death
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From HAMLET to XAMLET: The molecular complex selectively induces cancer cell death

机译：从HAMLET到XAMLET：分子复合物选择性诱导癌细胞死亡

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HAMLET (human α-lactalbumin made lethal to tumor cells) is a complex consisting of decalcinated α-lactalbumin and oleic acid. It has been shown to induce massive cell death in various cancers without serious damage to normal tissues in both?in vitro?and?in?vivo?experiments. The complexity of the mechanism in the cellular functions of HAMLET results from its heterogeneous compositions as revealed from the structural analyses, as well as its induction of the non-canonical cell responses different from the specific classical programmed cell death. As the remarkable progress was made in the studies of HAMLET in recent years, a variety of HAMLET-like substances have been demonstrated to exert similar biological activities to HAMLET. Here, we termed these species as the XAMLET, and overviewed the current findings in XAMLET studies for a better understanding of their functions and working mechanisms. This review might contribute to the improvement in the application of XAMLET towards clinical cancer therapies.
机译：HAMLET（对肿瘤细胞具有致死性的人α-乳白蛋白）是由脱钙的α-乳白蛋白和油酸组成的复合物。在体外和体内实验中，它已显示出在各种癌症中诱导大量细胞死亡而对正常组织没有严重损害的能力。该机制在HAMLET细胞功能中的复杂性来自结构分析揭示的其异质组成，以及其诱导的不同于特定经典程序性细胞死亡的非经典细胞应答。由于近年来在哈姆雷特的研究中取得了显着进展，因此已证明多种类似哈姆雷特的物质具有与哈姆雷特相似的生物活性。在这里，我们将这些物种称为XAMLET，并概述了XAMLET研究中的当前发现，以便更好地了解其功能和工作机制。这项审查可能有助于改进XAMLET在临床癌症治疗中的应用。

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