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首页> 外文期刊>African Journal of Biotechnology >Ultrasound sensitizes chemotherapy in chemoresistant ovarian cancers
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Ultrasound sensitizes chemotherapy in chemoresistant ovarian cancers

机译：超声波可提高化疗药物对卵巢癌的敏感性

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Chemotherapy resistance is still a great challenge to the management of ovarian cancers. Using SKOV3/ADR or COC1/DDP subline as a model of adriamycin- or cisplatin-resistance, ultrasonic chemosensitization was investigated. The addition of noncytotoxic insonation led to a higher cell-death rate as compared with a drug alone. Ultrasound sensitized chemotherapy via increasing intracellular drug accumulation, enhancing drug-induced apoptosis and decreasing the threshold dose for cell apoptosisecrosis. Ultrasound exposure enhanced cisplatin-induced DNA breakages in COC1/DDP cells but did not decrease the level of glutathione-S-transferase. Chemosensitization attributable to insonation was mostly mediated by cavitation. Ultrasonic chemotherapy had the property of a targeted treatment, in that the dose-anticancer effect and dose-toxicity curves differed from those in conventional chemotherapy. The findings indicated that ultrasound was a non-drug modality for sensitizing chemotherapy in refractory ovarian cancers.
机译：化疗耐药性仍然是卵巢癌治疗的巨大挑战。使用SKOV3 / ADR或COC1 / DDP亚线作为抗阿霉素或顺铂的模型，研究了超声化学增敏作用。与单独使用药物相比，添加非细胞毒性声波可导致更高的细胞死亡率。通过增加细胞内药物蓄积，增强药物诱导的细胞凋亡和降低细胞凋亡/坏死的阈值剂量，超声致敏化学疗法。超声暴露增强了顺铂诱导的COC1 / DDP细胞DNA断裂，但并未降低谷胱甘肽-S-转移酶的水平。归因于声共振的化学致敏作用主要由空化作用介导。超声化疗具有靶向治疗的特性，其剂量抗癌作用和剂量毒性曲线与常规化疗不同。研究结果表明，超声治疗是难治性卵巢癌敏化化疗的非药物方式。

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