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首页> 外文期刊>African Journal of Biotechnology >In vitro and in vivo preliminary results on Spirulina platensis for treatment of impetigo: Topical cream application
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In vitro and in vivo preliminary results on Spirulina platensis for treatment of impetigo: Topical cream application

机译：螺旋藻治疗脓疱疮的体外和体内初步结果：局部乳膏应用

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Impetigo is a highly infectious superficial bacterial disease, most common among pre-school children. Applying 11 antimicrobial agents to the?Staphylococcus aureus, the most causative organism for impetigo,?S. aureus?isolates are resistant to all agents except of?vancomycin and fusidic acid. Nevertheless, treatment of impetigo usingantimicrobial agents?may cause serious medical problems, such as destroying normal gut and skin flora and producing gastrointestinal irritations, dermatitis or serious hypersensitivity problems. Thus, the test of new microbial infection-fighting natural compounds is urgent.?The?in vitro?measuring the antibacterial activity ofSpirulina platensis?extracts, following agar-well diffusion method, against methicillin-resistant?S. aureus?(MRSA) and methicillin-sensitive?S. aureus?(MSSA) clinical isolates showed that the methanolic?S. platensis?extract is the most active. The?in vivo?efficacy of applied topical?S. platensis?creams, both methanolic extract and crude, in treatment of impetigo were compared. In general, clinical application of both active ingredients of?S. platensis?(Group 1-G1) and?crude?S. platensis?form (Group 2-G2) gave promising and excellent response rates. However, the Group 1 application had the best efficacy, no side effects and no recurrence during the follow-up period. Gas chromatography-mass spectrometry (GC-MS) analysis of both crude alga and its methanolic extract concludes that the potential antimicrobial activity is attributed to synergic effect of some fatty acids. We propose that the higher percentage of linoleic and palmitic acids and the presence of squalane in methanolic extract of?Spirulinamost probably are the causes of its higher antimicrobial activity.
机译：脓疱疮是一种高度传染性的浅表细菌性疾病，最常见于学龄前儿童。将11种抗菌药物应用于金黄色葡萄球菌，这是引起脓疱病的最致病菌。金黄色葡萄球菌对万古霉素和夫西地酸以外的所有药物均具有抗药性。然而，使用抗微生物剂治疗脓疱疮可能会引起严重的医学问题，例如破坏正常的肠道和皮肤菌群并产生胃肠道刺激，皮炎或严重的超敏反应问题。因此，测试新的抗微生物感染天然化合物的方法是紧急的。“体外”测量琼脂糖扩散法后，螺旋藻对耐甲氧西林的抗菌活性。金黄色葡萄球菌（MRSA）和对甲氧西林敏感的吗？金黄色葡萄球菌（MSSA）临床分离株显示出甲醇？S。高原提取物是最活跃的。局部应用S的体内功效。比较了用于治疗脓疱疮的白头翁乳膏，包括甲醇提取物和粗制奶油。通常，两种S的有效成分的临床应用。 platensis（Group 1-G1）和Scrude？S。平台形式（2-G2组）给出了有希望的出色的响应率。但是，在随访期间，第1组应用具有最佳疗效，无副作用且无复发。粗藻及其甲醇提取物的气相色谱-质谱（GC-MS）分析得出的结论是，潜在的抗菌活性归因于某些脂肪酸的协同作用。我们认为，螺旋藻的甲醇提取物中亚油酸和棕榈酸的比例较高以及角鲨烷的存在最可能是其抗菌活性较高的原因。

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