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首页> 外文期刊>African Journal of Biotechnology >Genotoxicity and oxidative stress induced by cadmium and zinc in the planarian, Dugesia dorotocephala
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Genotoxicity and oxidative stress induced by cadmium and zinc in the planarian, Dugesia dorotocephala

机译：镉和锌在the虫中的遗传毒性和氧化应激

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This study sought to determine the DNA damage, and the lipoperoxidative effect, as well as changes in the superoxide dismutase (SOD) and catalase (CAT) activities induced by CdSO4?(Cd), and ZnSO4?(Zn), in addition to two different mixtures of the metals. Planarian?Dugesia dorotocephala?collected in the Ignacio Ramirez reservoir, México, adapted to laboratory conditions, and exposed to the metals in a controlled system was used. Initially, LC50?at 96 h of exposure was determined and the result obtained were 0.69 mg/L for Cd, 11.99 mg/L for Zn, 10.28 mg/L for mix 1, and 8.11 mg/L for mix 2. Then, the comet assay showed a DNA damage increase induced by Cd (0.13 and 0.2 mg/L) as high as 94% over the control level; the effect by Zn (from 0.2 to 2.7 mg/L) was clearly lower, although statistically significant with the high concentrations tested. As regards the two mixtures, we observed a concentration dependent increase. Similarly, in respect to lipoperoxidation, we found a strong effect by Cd, a slight effect by Zn, and a concentration dependent effect induced by the mixtures. Finally, the activity of the tested enzymes was modified by the metals in relation to the concentration applied.
机译：这项研究试图确定CdSO4？（Cd）和ZnSO4？（Zn）引起的DNA损伤，脂过氧化作用以及超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性的变化，此外还涉及两种金属的不同混合物。使用了在墨西哥伊格纳西奥·拉米雷斯（Ignacio Ramirez）水库中收集的Planarian？Dugeto dorotocephala ?，它适合实验室条件，并在受控系统中暴露于金属。最初，测定暴露96 h的LC50，所得结果为Cd为0.69 mg / L，Zn为11.99 mg / L，混合物1为10.28 mg / L，混合物2为8.11 mg / L。彗星试验显示，镉引起的DNA损伤增加（0.13和0.2 mg / L）比对照水平高94％。锌的影响（0.2至2.7 mg / L）明显更低，尽管在高测试浓度下具有统计学意义。关于两种混合物，我们观察到浓度依赖性增加。类似地，就脂过氧化而言，我们发现Cd产生了强效，Zn产生了微弱的效应，以及混合物引起的浓度依赖性效应。最后，相对于所施加的浓度，测试的酶的活性被金属修饰。

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