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首页> 外文期刊>African Journal of Biotechnology >Antioxidative potential of polysaccharide fractions produced from traditional Chinese medicinal macrofungus Cordyceps jiangxiensis in vitro
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Antioxidative potential of polysaccharide fractions produced from traditional Chinese medicinal macrofungus Cordyceps jiangxiensis in vitro

机译：江西中草药冬虫夏草的多糖成分的体外抗氧化能力

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摘要

Cordyceps jiangxiensis, also called ‘CaoMuWang’, is a medicinal entomopathogenic macrofungus native to eastern China. Polysaccharide fractions from cultured?C. jiangxiensis?exhibited potent antitumor activity via the induction of cell cycle arrest and apoptotic pathway. Antioxidant pathway is also one action of mechanism of antitumor; thus, the antioxidant abilities of these polysaccharide fractions were overall evaluated by five?in vitro?assays such as the?scavenging abilities on DPPH·,?hydroxyl and superoxide anion radicals, the reducing power and the chelating ability on ferrous ions. Among these assays, the polysaccharide fractions presented more excellent scavenging abilities on superoxide anion radicals than that of the positive control. When compared with the positive control, the polysaccharide fractions from?C. jiangxiensis?only had moderate scavenging activities on both DPPH and hydroxyl free radicals, moderate reducing power and ferrous ion chelating activity. The antioxidant abilities of the different polysaccharide fractions had certain differences at all the tested doses and all had a dose-dependent manner. The results suggested that, polysaccharides are important antioxidant component in the medicinal?Cordyceps?fungi and have direct and potent antioxidant ability, and that?C. jiangxiensis?also is a promising potential source for the development of natural antioxidant.
机译：江西冬虫夏草，又称“草木王”，是一种产于中国东部的药用昆虫病原性大型真菌。来自培养的C的多糖级分。江西通过诱导细胞周期停滞和凋亡途径表现出强大的抗肿瘤活性。抗氧化途径也是抗肿瘤机制的作用之一。因此，通过五种体外测定法对这些多糖级分的抗氧化能力进行了总体评估，例如对DPPH·，β-羟基和超氧阴离子自由基的清除能力，对亚铁离子的还原能力和螯合能力。在这些测定中，多糖级分对超氧阴离子自由基的清除能力优于阳性对照。与阳性对照相比，多糖级分来自℃。江西只对DPPH和羟基自由基具有中等清除能力，对还原力和亚铁离子螯合活性中等。在所有测试剂量下，不同多糖组分的抗氧化能力均存在一定差异，并且均具有剂量依赖性。结果表明，多糖是药用“冬虫夏草”真菌中重要的抗氧化剂成分，具有直接有效的抗氧化能力。江西也是天然抗氧化剂发展的有希望的潜在来源。

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