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首页> 外文期刊>African Journal of Biotechnology >Toxins and adhesion factors associated with Staphylococcus aureus strains isolated from diarrhoeal patients in Benin
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Toxins and adhesion factors associated with Staphylococcus aureus strains isolated from diarrhoeal patients in Benin

机译：贝宁腹泻患者分离出的金黄色葡萄球菌菌株相关毒素和粘附因子

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Staphylococcus aureus?is a causative agent of acute and infectious diarrhoea. In Africa, there is no sufficient information on the virulence and the degree of factors produced by its diarrhoea-isolated strains. Clinical features and virulence factors produced by?S. aureus?isolated from diarrhoeal-patients admitted at the Hospital Hubert Koutoukou Maga (HKM) in Cotonou was investigated. The virulence factors were screened by radial immunoprecipitation and multiplex polymerase chain reaction (PCR). Fifteen antibiotics were tested. Among independent 115 patients examined for diarrhoea, 32 had faeces positive for?S. aureus?isolated as pure culture. Most of these patients were hospitalized (21/32) and developed aqueous, bloody and painful diarrhoea, after antimicrobial therapy. About 62% were resistant to oxacillin. Genes encoding for clumping factor B and for laminin binding protein were detected in 62% of?S. aureus?isolates. About 94% of LukE-LukD producing strains have been isolated from patients developing post-antibiotic associated diarrhoea (PAAD). The Panton-Valentine Leucocidin (PVL) was produced by 19% of isolates, all from PAAD. This study points out new data concerning virulence factors and adhesion factor produced by?S. aureus?strains isolated from diarrhoea in Benin. The culture of the faeces will not always allow the diagnosis. It is important to update a technique, which enables researchers to carry out the virulence factors produced by these bacteria.
机译：金黄色葡萄球菌是急性和感染性腹泻的病原体。在非洲，没有足够的信息说明其腹泻分离株的毒力及其产生的程度。 S？产生的临床特征和毒力因子。从在科托努的休伯特·库图库·玛格医院（HKM）住院的腹泻患者中分离出金黄色葡萄球菌。通过放射免疫沉淀和多重聚合酶链反应（PCR）筛选毒力因子。测试了十五种抗生素。在独立的115例腹泻患者中，有32例粪便的S？S阳性。金黄色葡萄球菌？分离为纯培养物。这些患者中的大多数在抗菌治疗后住院（21/32），并出现了房水，血性和腹泻性腹泻。约62％的人对奥沙西林有抗药性。在62％的？S中检测到编码成簇因子B和层粘连蛋白结合蛋白的基因。金黄色葡萄球菌？从发生抗生素后相关性腹泻（PAAD）的患者中分离出大约94％的产生LukE-LukD的菌株。 Panton-Valentine Leucocidin（PVL）由19％的分离物生产，全部来自PAAD。这项研究指出了有关？S产生的毒力因子和粘附因子的新数据。从贝宁腹泻分离出的金黄色葡萄球菌菌株。粪便的培养并不总是可以进行诊断的。重要的是要更新一种技术，使研究人员能够执行这些细菌产生的毒力因子。

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