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首页> 外文期刊>African Journal of Biotechnology >Cactus (Opuntia ficus indica) extract improves endoplasmic reticulum stress in Drosophila melanogaster
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Cactus (Opuntia ficus indica) extract improves endoplasmic reticulum stress in Drosophila melanogaster

机译：仙人掌（仙人掌）提取物改善果蝇内质网应激

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We reported in this paper the requirement of the extract of cactus (Opuntia ficus indica) for regulating unfolded protein response (UPR) target genes and maintaining endoplasmic reticulum (ER) homeostasis. The endoplasmic reticulum (ER) is a subcellular organelle where many proteins are synthesized and sorted to various subcellular destinations. Accumulation of unfolded protein in ER can induce a stress. The ER responds to stress by initiating a cascade of events known as the "unfolded protein response" (UPR). The UPR pathway is triggered by sensors located at the ER membrane. Here, we analyzed a branch of the UPR mediated by ire-1/xbp-1?in?Drosophila?to establish its regulation by aqueous extract from fruits and cladode of cactus "Opuntia ficus indica". In?Drosophila, the?Dxbp-1?transcript was submitted to an “unconventional” splicing induced by IRE1 endoribonucease that generated a processed?Dxbp-1s?transcript encoding a?Dxbp-1?protein isoform. The?Dxbp-1s?is a key regulator in UPR to activate genes involved in folding and degradation to restore ER function. Here, we investigated the interaction between ER stress and bimolecular extract from cactus?O. ficus indica?which is a xerophyte that play multiple functions in medicine with anti-ulcer, anti-diabetic and anti-oxidants properties. We showed that the aqueous extract from fruit and cladode ofO. ficus indica?regulated ER stress mediated by the modulation of the unconventional splicing of mRNA?xbp-1?and for transcription of?bip?RNA. A good correlation was found between ire-1/xbp-1?expression and?bip?expression.
机译：我们在本文中报告了仙人掌提取物（印度仙人掌）对调节未折叠蛋白反应（UPR）靶基因和维持内质网（ER）稳态的需求。内质网（ER）是亚细胞器，其中许多蛋白质被合成并分类到各种亚细胞目的地。内质网中未折叠蛋白的积累会引起压力。 ER通过启动一系列事件来响应压力，这些事件被称为“未折叠蛋白反应”（UPR）。 UPR路径由位于ER膜的传感器触发。在这里，我们分析了在果蝇中由ire-1 / xbp-1′介导的UPR的一个分支，以通过仙人掌“ Opuntia ficus indica”的果实和枝条的水提物建立其调节作用。在果蝇中，Dxbp-1转录物被IRE1内切核糖核酸酶诱导的“非常规”剪接，该剪接产生编码Dxbp-1α蛋白同工型的加工过的Dxbp-1s转录物。 Dxbp-1s是UPR中的关键调节剂，其激活参与折叠和降解的基因以恢复ER功能。在这里，我们研究了内质网应激与仙人掌？O的双分子提取物之间的相互作用。榕属植物-旱生植物，在医学上起着多种作用，具有抗溃疡，抗糖尿病和抗氧化剂的特性。我们证明了从O的果实和枝条提取的水提取物。榕cus调节内质网的内质网应激，该内质网应激是通过调节mRNA？xbp-1？的非常规剪接和？bip？RNA的转录介导的。发现ire-1 / xbp-1表达与bip表达之间具有良好的相关性。

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