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首页> 外文期刊>African Journal of Biotechnology >Sapucaia nuts (Lecythis pisonis) modulate the hepatic inflammatory and antioxidant metabolism activity in rats fed high-fat diets
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Sapucaia nuts (Lecythis pisonis) modulate the hepatic inflammatory and antioxidant metabolism activity in rats fed high-fat diets

机译：Sapucaia坚果（Lecythis pisonis）调节高脂饮食大鼠的肝脏炎症和抗氧化代谢活性

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摘要

Lecythis pisonis Cambess is commonly known as “sapucaia” nut. Previous studies show that it is rich in unsaturated fatty acids and in antioxidant minerals. The aim of the present study was to assess the antioxidant and anti-inflamatory effects of this nut after its introduction into a control (AIN-93G) or high-fat diet in Wistar rats. The animals were divided into four groups: a control diet, the same control diet supplemented with sapucaia nuts, a high-fat diet or the high-fat diet supplemented with sapucaia nuts and were fed with these diets for 14 or 28 days. The gene expression of the markers tumor necrosis factor (TNF)-α NFκB (p65) zinc superoxide dismutase (ZnSOD) and heat shock protein 72 (HSP72) was determined by the chain reaction to the quantitative reverse transcription-polymerase chain reaction (q-PCR). The antioxidant activity was also measured as thiobarbituric acid reactive substances (TBARS) through the activity of the SOD enzyme. The groups treated with “sapucaia” nuts presented reduced lipid peroxidation values and increased ZnSOD and HSP72 gene expression, as well as decreased TNF-α and NFκB (p65) gene expression levels. The significant results showed that “sapucaia” could serve as a potential source of antioxidants and as a protector agent for the examined animals.
机译：金钱草坎贝斯通常被称为“ sapucaia”坚果。先前的研究表明，它富含不饱和脂肪酸和抗氧化剂矿物质。本研究的目的是评估将这种坚果引入Wistar大鼠的对照（AIN-93G）或高脂饮食中后的抗氧化和抗炎作用。将动物分为四组：对照饮食，补充有sapucaia坚果的相同对照饮食，高脂饮食或补充有sapucaia坚果的高脂肪饮食，并用这些饮食喂养14或28天。通过定量反转录-聚合酶链反应的链反应来确定肿瘤坏死因子（TNF）-αNFκB（p65）超氧化锌歧化酶（ZnSOD）和热休克蛋白72（HSP72）的基因表达。 PCR）。还通过SOD酶的活性将抗氧化剂活性测量为硫代巴比妥酸反应性物质（TBARS）。用“ sapucaia”坚果治疗的组表现出降低的脂质过氧化值，并增加ZnSOD和HSP72基因表达，并降低TNF-α和NFκB（p65）基因表达水平。显着结果表明，“乌贼”可作为潜在的抗氧化剂来源和被检动物的保护剂。

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