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首页> 外文期刊>African Journal of Cellular Pathology >The effect of ascorbic acid on mercury-induced changes on the histomorphology of the cerebellum of adult wistar rats
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The effect of ascorbic acid on mercury-induced changes on the histomorphology of the cerebellum of adult wistar rats

机译：抗坏血酸对汞诱导的变化对成年wistar大鼠小脑组织形态的影响

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Aim: The present study was aimed at evaluating the effect of ascorbic acid on mercury-induced changes on the cerebellar cortex of adult Wistar rats.Methods: Thirty adult Wistar rats of average weight of 200g were randomly divided into 6 groups of 5 rats each. The animals in Group 1 (control) were administered with distilled water, Groups 2 and 3 were administered with 52mg/kg and 26.25mg/kg body weight of HgCl2 respectively while Groups 4 and 5 were administered with 52mg/kg of HgCl2 and 5mg/kg of ascorbic acid and 26.25gm/kg of HgCl2 and 5mg/kg of ascorbic acid respectively, while Group 6 was administered with 5mg/kg of ascorbic acid. The administration was through the oral route, daily for 3 weeks and the animals were humanely sacrificed. Thereafter, blood and tissue samples were harvested for analysis.Results: The result of the biochemical parameters showed a significant increase (P<0.05) in the mean SOD and LPO values after the administration of mercuric chloride and ascorbic acid. Histological observation of the cerebellar cortex showed normal histo-morphology in Groups 1 and 6 while, the cerebellum in Groups 2, 3, 4 and 5 showed some degenerative, necrotic and cellular changes.Conclusion: Ascorbic acid administration has shown to ameliorate the induced degenerative changes in the cerebellum caused by mercuric chloride toxicity in Wistar rats.
机译：目的：本研究旨在评估抗坏血酸对汞诱导的成年Wistar大鼠小脑皮层变化的影响。方法：将30只平均体重200g的成年Wistar大鼠随机分为6组，每组5只。第1组（对照组）的动物被给予蒸馏水，第2和第3组分别给予52mg / kg和26.25mg / kg体重的HgCl2，而第4和第5组则给予52mg / kg的HgCl2和5mg / kg。 kg抗坏血酸和26.25gm / kg HgCl2和5mg / kg抗坏血酸，而第6组则服用5mg / kg抗坏血酸。通过口服途径给药，每天3周，并且人道地处死动物。结果：生化参数结果显示，氯化汞和抗坏血酸给药后，平均SOD和LPO值显着增加（P <0.05）。小脑皮层的组织学观察显示第1和第6组的组织形态正常，而第2、3、4和5组的小脑表现出一些退行性，坏死性和细胞性变化。 Wistar大鼠氯化汞毒性引起的小脑变化。

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