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首页> 外文期刊>African Journal of Biotechnology >Antiproliferation and apoptosis induction of phytic acid in hepatocellular carcinoma (HEPG2) cell lines
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Antiproliferation and apoptosis induction of phytic acid in hepatocellular carcinoma (HEPG2) cell lines

机译：植酸在肝细胞癌（HEPG2）细胞系中的抗增殖和凋亡诱导

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摘要

Phytic acid is a naturally occurring polyphosphorylated carbohydrate, present ubiquitous in plants and animals. It is not only a natural antioxidant, but may also be the precursor/storage of intracellular inositol phosphates, important for various cellular functions and potential as anticancer compound. A prominent anticancer action of phytic acid has been demonstrated both?in vivo?and?in vitro?in a variety of tumor types, possibly through inhibition of tumor cell growth and differentiation. In this study, the growth inhibitory effect of phytic acid extracted from rice bran on hepatocellular cell lines (HEPG2), cell cycle modulation and apoptosis?induction were undertaken. Phytic acid prove to induce growth inhibition and differentiation in HepG2in a dose and time-dependent manner with IC50?value of 17.0 μg/ml. Analysis of flow cytometry was performed for the analysis of cell cycle and apoptosis. Treatment of phytic acid against HepG2?also resulted in cell cycle arrest in HEPG2?cell at G2/M phase cell cycle arrest. Besides, Annexin V-assay and propidium iodide confirmed the apoptosis occurred early and late in the cell line. In conclusion,?with the?resultstaken?from our findings, phytic acid extracted from rice bran?was?revealed as a potent candidate for adjuvant chemotherapy and prevention of cancer.
机译：植酸是一种天然存在的多磷酸化碳水化合物，在植物和动物中普遍存在。它不仅是天然的抗氧化剂，而且还可能是细胞内肌醇磷酸酯的前体/储存物，对各种细胞功能和作为抗癌化合物的潜力很重要。植酸在多种肿瘤类型的体内和体外均具有显着的抗癌作用，可能是通过抑制肿瘤细胞的生长和分化来实现的。在这项研究中，从米糠中提取的植酸对肝细胞系（HEPG2）的生长抑制作用，细胞周期的调控和细胞凋亡的诱导被进行。植酸被证明以剂量和时间依赖性的方式诱导HepG2的生长抑制和分化，IC5​​0值为17.0μg/ ml。进行流式细胞仪分析以分析细胞周期和凋亡。对HepG2α的植酸处理也导致HEPG2β细胞在G2 / M期细胞周期停滞中的细胞周期停滞。此外，Annexin V-测定法和碘化丙锭证实了细胞系中早期和晚期发生了凋亡。总之，通过我们的发现，可以发现从米糠中提取的植酸被认为是辅助化疗和预防癌症的有效候选药物。

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