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首页> 外文期刊>African Journal of Laboratory Medicine >Blueprint for building a biorepository in a resource-limited setting that follows international best practices
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Blueprint for building a biorepository in a resource-limited setting that follows international best practices

机译：在遵循国际最佳实践的资源有限的环境中建立生物资源库的蓝图

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ackground: Genetic diversity is abundant on the African continent. However, genomic research has been hampered by a lack of high quality and extensively annotated biospecimens and the necessary infrastructure to support such a technology-intensive effort. Objective: The Institute of Human Virology Nigeria (IHVN) partnered with the H3Africa Consortium and the Coriell Institute for Medical Research to build an internationally recognised biorepository for the receipt, processing, storage and distribution of biospecimens for biomedical research. Here, the authors describe the procedures, challenges and results encountered. Results: Key requirements for a high-quality biorepository were identified: (1) institutional support of infrastructure and services, (2) on-site trained staff with primary commitment to the biorepository, (3) reliance on best practices from globally recognised biorepository groups, (4) early implementation of a quality management system, (5) adoption of a laboratory information management system with demonstrated versatility in functions, (6) collaboration with external experts and sharing of experience through abstracts, newsletters, published manuscripts, and attendance at meetings and workshops, (7) strict adherence to local and national ethical standards and (8) a sustainability plan that is reviewed and updated annually. Conclusion: Utilising published best practices of globally recognised experts in the biorepository field as a benchmark, IHVN expanded and reorganised its existing laboratory facility and staff to take on this new purpose.
机译：背景：非洲大陆遗传多样性丰​​富。然而，基因组研究由于缺乏高质量和广泛注释的生物样本以及支持这种技术密集型工作的必要基础设施而受到阻碍。目的：尼日利亚人类病毒学研究所（IHVN）与H3Africa财团和科里尔医学研究所合作，建立了一个国际认可的生物储存库，用于生物医学研究的生物样本的接收，加工，储存和分配。在这里，作者描述了程序，遇到的挑战和遇到的结果。结果：确定了高质量生物存储库的关键要求：（1）基础设施和服务的机构支持;（2）对生物存储库有主要承诺的现场培训人员;（3）依赖全球公认的生物存储库组的最佳实践;（4）尽早实施质量管理体系;（5）采用功能证明具有多功能性的实验室信息管理系统;（6）与外部专家合作，并通过摘要，时事通讯，已发表的手稿以及参加会议分享经验会议和讲习班，（7）严格遵守当地和国家的道德标准，以及（8）每年审查和更新的可持续发展计划。结论：IHVN以已发表的生物存储领域全球公认专家的最佳实践为基准，扩展并重组了其现有实验室设施和员工，以实现这一新目的。

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