...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>African Journal of Laboratory Medicine >Candidaemia in a tertiary hospital in Nigeria
【24h】

Candidaemia in a tertiary hospital in Nigeria

机译：尼日利亚一家三级医院的念珠菌血症

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Candidaemia is a widely-studied and reviewed topic in the developed world; however, there is a dearth of information on nosocomial candidaemia in Nigeria, despite the increasing use of more invasive therapeutic modalities, immunosuppressive agents and increasing incidence of immunosuppression as a result of malignancies and HIV.Objectives: To determine the hospital-based frequency of candidaemia in a tertiary hospital in Ibadan, Nigeria.Method: This was a prospective descriptive study which included 230 immunosuppressed patients. All isolates were identified to the species level using both conventional and automated methods. Thereafter, all?Candida species isolated were tested for antifungal susceptibility using the broth microdilution method.Results: Candidaemia occurred in 12 (5.21%) of the 230 study patients, with?C. tropicalis accounting for 50% of the infections. Four patients (33.3%) presented with?C. parapsilosis, one (8.3%) with?C. albicans and one (8.3%) with a mixed infection of?C. albicans and?C. tropicalis. All 12 isolates were sensitive to fluconazole (minimal inhibitory concentration 8 mg/mL). Univariate analysis revealed that old age, multiple surgeries and long-term hospitalisation were significant contributing factors for the occurrence of candidaemia. Eleven (91.7%) of the 12 patients with candidaemia had?Candida colonisation of other sterile sites including the bladder, peritoneum and trachea. Furthermore, bivariate analysis revealed that mucositis (p = 0.019) and diarrhoea (p = 0.017) were significantly associated with an increased risk of candidaemia. The crude mortality rate of candidaemia was 91.7%.Conclusion: This study highlights the significance of nosocomial candidaemia and the need for proactive laboratory investigation and clinical management of this life-threatening disease.
机译：背景：念珠菌血症是发达国家广泛研究和审查的话题。然而，尽管由于恶性肿瘤和艾滋病毒导致越来越多的侵入性治疗手段，免疫抑制剂的使用和免疫抑制发生率的增加，但尼日利亚尚缺乏关于医院念珠菌血症的信息。目的：确定医院中念珠菌血症的发生频率方法：这是一项前瞻性描述性研究，其中包括230名免疫抑制患者。使用常规方法和自动化方法将所有分离物鉴定到物种水平。此后，使用肉汤微量稀释法检测所有分离的念珠菌种类的抗真菌药敏性。结果：230例研究对象的12例念珠菌血症（5.21％）发生于C。热带病占感染的50％。 4例患者（33.3％）表现为？C。副截瘫，一名（8.3％）患有？C。白色念珠菌和一种（8.3％）混合感染？C。白色念珠菌和？热带。所有12个分离株均对氟康唑敏感（最低抑菌浓度<8 mg / mL）。单因素分析显示，老年，多次手术和长期住院是造成念珠菌血症的重要因素。 12例念珠菌血症患者中有11例（91.7％）的念珠菌定植在其他无菌部位，包括膀胱，腹膜和气管。此外，双变量分析表明，粘膜炎（p = 0.019）和腹泻（p = 0.017）与念珠菌血症的风险增加显着相关。念珠菌血症的总死亡率为91.7％。结论：本研究强调了医院念珠菌血症的重要性以及需要对此种威胁生命的疾病进行积极的实验室研究和临床管理。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号