The gene expressions of DNA methylation/demethylation enzymes and cytochrome c oxidase subunit 4 in skeletal muscle of thyroidectomized rats

Shuhong Peng; Ningying Xu Liping Huang; Xiaoheng Gao Weifeng Zhu Riyue Yu; Hongning Liu

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The gene expressions of DNA methylation/demethylation enzymes and cytochrome c oxidase subunit 4 in skeletal muscle of thyroidectomized rats

机译：甲状腺切除大鼠骨骼肌DNA甲基化/去甲基化酶和细胞色素c氧化酶亚基4的基因表达

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A decrease in?mRNA levels?for?cytochrome?c oxidase?(COX)?subunits wasobserved?in skeletal muscle of?hypothyroid rats.?However, the precise expression mechanisms?of the related?genes?in?hypothyroid state?still remain unclear. This study investigated gene expressions?of DNA methyltransferases (Dnmts), DNA demethylases and?Cox4?in skeletal muscle of thyroidectomized rats. The findingsshowed that,?the?mRNA levels of genes encoding?Dnmts?and DNA demethylases were up-regulated?while?the mRNA levels of?Cox4?down-regulated. These resultsimply?that, DNA methylation might down-regulate?Cox4?expression?and induce?a compensatory mechanism for avoiding an excessive incorporation of 5-mC into DNA.

机译：在甲状腺功能减退大鼠的骨骼肌中观察到细胞色素c氧化酶（COX）亚基的mRNA水平降低。但是，甲状腺功能减退状态下相关基因的精确表达机制仍然存在。不清楚。这项研究调查了在甲状腺切除的大鼠骨骼肌中DNA甲基转移酶（Dnmts），DNA脱甲基酶和？Cox4？的基因表达。研究结果表明，编码Dnmts和DNA脱甲基酶的基因的mRNA水平被上调，而Cox4的mRNA水平被下调。这些结果表明，DNA甲基化可能会下调“ Cox4”的表达并诱导一种补偿机制，从而避免5mC过度掺入DNA。

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《African Journal of Biotechnology》 |2011年第5期|共4页
作者
Shuhong Peng; Ningying Xu Liping Huang; Xiaoheng Gao Weifeng Zhu Riyue Yu; Hongning Liu;
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中图分类生物工程学（生物技术）;
关键词
Gene expressionDnmtsMbd4Gadd45αCox4;

机译：基因表达DnmtsMbd4Gadd45αCox4;

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1. The gene expressions of DNA methylation/demethylation enzymes and cytochrome c oxidase subunit 4 in skeletal muscle of thyroidectomized rats [J] . Shuhong Peng, Ningying Xu Liping Huang, Xiaoheng Gao Weifeng Zhu Riyue Yu, African Journal of Biotechnology . 2011,第5期

机译：甲状腺切除大鼠骨骼肌DNA甲基化/去甲基化酶和细胞色素c氧化酶亚基4的基因表达
2. Deletion of heart-type cytochrome c oxidase subunit 7a1 impairs skeletal muscle angiogenesis and oxidative phosphorylation [J] . LeeI., HüttemannM., LiuJ., The Journal of Physiology . 2012,第20期

机译：心脏型细胞色素C氧化酶亚基7a1的缺失损害骨骼肌血管生成和氧化磷酸化
3. Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on the in vivo cytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA [J] . Giri, Delvadia, Gupta, Xenobiotica: the fate of foreign compounds in biological systems . 2018,第1a12期

机译：在大鼠体内细胞色素P450 2D（CYP2D）酶的喹硫吡啶与奎尼丁的每日皮质类固醇给药的后果：对右三甲苯酚的O-去甲基化活性和CYP2D1 mRNA的表达水平的影响
4. Synergistic effects of combination of three wavelengths and different light sources in cytochrome c oxidase activity in intact skeletal muscle of rats [C] . Ernesto Cesar Pinto Leal-Junior, Shaiane da Silva Tomazoni SPIE Conference on Medical Laser Applications and Laser-Tissue Interactions . 2019

机译：三个波长和不同光源组合在大鼠完整骨骼肌中细胞色素C氧化酶活性中的不同光源的协同作用
5. Identification and phylogenetic relationships within the genus Tetrahymena using the cytochrome c oxidase subunit 1 gene and the small subunit ribosomal RNA gene. [D] . Chantangsi, Chitchai. 2006

机译：使用细胞色素c氧化酶亚基1基因和小亚基核糖体RNA基因鉴定和鉴定四膜虫内的系统发育关系。
6. Deletion of heart-type cytochrome c oxidase subunit 7a1 impairs skeletal muscle angiogenesis and oxidative phosphorylation [O] . Icksoo Lee, Maik Hüttemann, Jenney Liu, 2012

机译：心脏型细胞色素C氧化酶亚基7a1的缺失损害骨骼肌血管生成和氧化磷酸化
7. Developmentally regulated expression of cytochrome-c oxidase isoforms in regenerating rat skeletal muscle [O] . Chalermporn Ongvarrasopone, John M. Kennedy 1998

机译：在再生大鼠骨骼肌中的细胞色素-C氧化酶同种型的发育调节表达

The gene expressions of DNA methylation/demethylation enzymes and cytochrome c oxidase subunit 4 in skeletal muscle of thyroidectomized rats

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