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首页> 外文期刊>African Journal of Biotechnology >Evaluation of haematological and plasma biochemical effects of aqueous extracts of Parkia biglobosa seeds in rats
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Evaluation of haematological and plasma biochemical effects of aqueous extracts of Parkia biglobosa seeds in rats

机译：大叶Parkia biglobosa种子水提物对大鼠血液学和血浆生化作用的评价

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摘要

The effects of sub-acute exposure to aqueous extract of Parkia biglobosa seeds on haematology and plasma biochemical parameters were studied. Twenty eight male Wistar albino rats were orally ingested with 0, 200, 400 and 800 mgkg-1 dose of the extract for 21 days and were sacrificed. Haematological parameters were assessed: red blood cell counts, haematocrit and haemoglobin concentration significantly (p<0.05) increased at the 800 mgkg-1 dose. We also observed significant increases in white blood cells, lymphocytes and neutrophils at this dose. Evaluation of effect of seed extract on plasma biochemical values revealed significant increase in total protein, albumin and aspartate amino transferase. However, the extract caused significant decrease (p < 0.05) in the levels of blood urea nitrogen and creatinine. Changes observed in plasma levels of globulin, alanine amino-transferase (ALT) and gamma-glutamyl transferase (GGT) were not significantly different from the control at all treatment doses.
机译：研究了亚急性暴露于Parkia biglobosa种子水提物对血液学和血浆生化参数的影响。口服摄入0、200、400和800 mgkg-1剂量的提取物对28只雄性Wistar白化病大鼠进行21天的实验并处死。评估血液学参数：在800 mgkg-1剂量下，红细胞计数，血细胞比容和血红蛋白浓度显着增加（p <0.05）。我们还观察到在此剂量下白细胞，淋巴细胞和中性粒细胞显着增加。种子提取物对血浆生化值的影响评估显示总蛋白，白蛋白和天冬氨酸氨基转移酶显着增加。但是，提取物导致血尿素氮和肌酐水平显着降低（p <0.05）。在所有治疗剂量下，血浆中球蛋白，丙氨酸氨基转移酶（ALT）和γ-谷氨酰转移酶（GGT）水平的变化均与对照组无显着差异。

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