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首页> 外文期刊>African Journal of Cellular Pathology >EVALUATION OF THE TOXICITY OF PHYLLANTHUS AMARUS IN WISTAR ALBINO RATS
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EVALUATION OF THE TOXICITY OF PHYLLANTHUS AMARUS IN WISTAR ALBINO RATS

机译：猕猴桃中PHY肉的毒性评价

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Aim: The study evaluated the acute and sub acute toxicity of the aqueous leaf extract of Phyllathus amarus Schum. and Thonn using Wistar albino rat.Methods: Sixty-one adult Wistar rats were grouped four groups with ten rats per group for acute study. Rats in group 2, 3 and 4 received 2000mg/kg, 4000mg/kg, and 8000mg/kg of the extract respectively. For sub acute study, rats were divided into three groups with seven per group. Rats in groups 2 and 3 received 2000mg/kg and 4000mg/kg of the extract respectively. Blood was obtained by cardiac puncture. The heart, liver and kidney of each rat were also excised, weighed and used for biochemical and histopathological analysis.Results: The acute toxicity study revealed that the oral administration of the extract was safe up to the dose level of 8,000mg/kg. Besides the significant (P<0.05)? increase in kidney AST 48hrs after acute exposure and significant reduction in plasma ALP in sub-acute exposure, no abnormality in plasma and tissue biochemical markers was observed. There was noneffect on the renal function indices but increase in WBC after sub-acute exposure. The gross and histopathological examination of the kidney and liver after both acute and sub acute study showed minor abnormalities.Conclusion: Therefore, it can be concluded that P.amarus aqueous extract is safe, as oral administration has no adverse effect on rat liver and kidney.Keywords: Acute, subacute toxicity, Phyllanthus amarus, Medicinal plant.
机译：目的：该研究评估了Phyllathus amarus Schum的叶片提取物的急性和亚急性毒性。方法：将61只成年Wistar大鼠分为四组，每组十只，用于急性研究。第2、3和4组的大鼠分别接受2000mg / kg，4000mg / kg和8000mg / kg的提取物。为了进行亚急性研究，将大鼠分成三组，每组七只。第2组和第3组的大鼠分别接受2000mg / kg和4000mg / kg的提取物。通过心脏穿刺获得血液。还切除了每只大鼠的心脏，肝脏和肾脏，称重并用于生化和组织病理学分析。结果：急性毒性研究表明，口服提取物的安全剂量最高为8,000mg / kg。除了显着（P <0.05）？急性暴露后48小时肾脏AST升高，亚急性暴露后血浆ALP显着降低，未观察到血浆和组织生化指标异常。亚急性暴露后对肾功能指标无影响，但白细胞增加。急性和亚急性研究后对肾脏和肝脏的肉眼和组织病理学检查均显示较小的异常。结论：因此，可以得出结论，P.amarus水提取物是安全的，因为口服对大鼠肝脏和肾脏没有不良影响关键词：急性，亚急性毒性，Ph兰，药用植物。

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