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Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort

机译：老年人的全身性炎症和认知障碍的可改变危险因素：来自英国出生队列的发现

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Serum pro‐inflammatory markers may contribute to dementia pathophysiology and cognitive impairment. In a population‐representative birth cohort, serum C‐reactive protein (CRP), interleukin‐6 (IL‐6), and white cell count (WCC) were measured at age 60‐64 years and cognition was assessed using the Addenbrooke's Cognitive Examination (ACE‐III) at age 69 years. Higher baseline CRP and IL‐6 were associated with lower ACE‐III scores, but associations were attenuated on adjustment for educational attainment, sex, and other modifiable life course factors. No associations were found for CRP, IL‐6, and WCC with visual search speed or verbal memory. In conclusion, the relationship between increased baseline systemic inflammation and poorer cognition in later life may be explained by, or share pathways with, education and other modifiable life course factors.
机译：血清促炎标记物可能有助于痴呆症的病理生理和认知功能障碍。在以人口为代表的出生队列中，在60-64岁时测量了血清C反应蛋白（CRP），白细胞介素6（IL-6）和白细胞计数（WCC），并使用Addenbrooke的认知检查评估了认知度（ACE-III），享年69岁。较高的基线CRP和IL-6与较低的ACE-III得分相关，但是随着受教育程度，性别和其他可改变的生活过程因素的调整，相关性减弱。没有发现CRP，IL-6和WCC与视觉搜索速度或口头记忆有关。总之，基线系统性炎症增加与以后生活中较差的认知之间的关系可以通过教育和其他可改变的生命过程因素来解释，或与之共享途径。

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