emPDE4B/em gene polymorphism in Russian patients with panic disorder

Alena V Malakhova; Olga I Rudko; Vladimir V Sobolev; Artemii V Tretiakov; Elena A Naumova; Zarema G Kokaeva; Julia E Azimova; Eugene A Klimov

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emPDE4B/em gene polymorphism in Russian patients with panic disorder

机译：俄罗斯恐慌症患者 PDE4B 基因多态性

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Background : Panic disorder is a complex disease of unclear etiology but with an apparent genetic component. PDE4B gene product is involved in many cell processes owing to its function-regulation of the level of a second messenger cAMP. PDE4B gene polymorphism has been shown to be associated with some mental disorders including panic disorder. Aims : The goal of our study was to evaluate the role of 3 SNPs in the PDE4B gene in the development of panic disorder. Methods : 94 patients diagnosed with panic disorder according to the DSM-IV criteria were enrolled in the study. The population control group included 192 subjects. Genotyping was carried out by real-time PCR with TaqMan probes. Results : The investigated substitutions are not associated with panic disorder in general and in female/male cohorts (p 0.05). The analysis of complex genotypes demonstrated two protective complex genotypes (rs1040716:A, T + rs10454453:A + rs502958:A and rs1040716:A, T + rs502958:A) associated with panic disorder in general regardless of the patient’s gender (p 0.05). These genotypes did not correlate with the patient’s sex. Conclusions: We found two complex protective genotypes associated with panic disorder. This can be due to the fact that predisposition to the disease are associated with other genes, while PDE4B gene polymorphism reduces their effect. 展开▼

机译：背景：恐慌症是一种病因不明但具有明显遗传成分的复杂疾病。 PDE4B基因产物由于其功能调节第二信使cAMP的水平而参与许多细胞过程。已经显示PDE4B基因多态性与一些精神障碍，包括惊恐障碍有关。目的：我们的研究目的是评估PDE4B基因中的3个SNP在恐慌症发展中的作用。方法：纳入符合DSM-IV标准的94例恐慌症患者。人口对照组包括192名受试者。使用TaqMan探针通过实时PCR进行基因分型。结果：在一般情况下以及在女性/男性队列中，研究的替代与恐慌症无关（p> 0.05）。复杂基因型的分析表明，与患者的性别无关，通常有两种与恐慌症相关的保护性复杂基因型（rs1040716：A，T + rs10454453：A + rs502958：A和rs1040716：A，T + rs502958：A），与患者的性别无关（p <0.05））。这些基因型与患者的性别无关。结论：我们发现了两种与恐慌症相关的复杂保护性基因型。这可能是由于该疾病的易感性与其他基因有关，而PDE4B基因多态性降低了它们的作用。展开▼

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《AIMS Genetics》 |2019年第3期|共9页

作者
Alena V Malakhova; Olga I Rudko; Vladimir V Sobolev; Artemii V Tretiakov; Elena A Naumova; Zarema G Kokaeva; Julia E Azimova; Eugene A Klimov;
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中图分类遗传学;

关键词
PDE4B geners10454453rs502958rs1040716panic disordergenetic association;

机译：PDE4B Geners10454453rs502958rs1040716恐慌症遗传关联;

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2. Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder. [J] . Unschuld PG, Ising M, Erhardt A, Journal of affective disorders . 2008,第1a3期

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3. PS248. The Interaction Effects between Panic-Related Genes Polymorphisms and Panic Disorder on Cortical Thickness of Paralimbic Regions: A Preliminary Study [J] . The international journal of neuropsychopharmacology . 2016,第Suppla1期

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6. PDE4B gene polymorphism in Russian patients with panic disorder [O] . Alena V Malakhova, Olga I Rudko, Vladimir V Sobolev, 2019

机译：俄罗斯恐慌症患者PDE4B基因多态性

7. PDE4B gene polymorphism in Russian patients with panic disorder [O] . Alena V Malakhova, Olga I Rudko, Vladimir V Sobolev, 2019

机译：PDE4B俄罗斯患者恐慌症患者的基因多态性

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机译：组成，治疗患有抑郁症，广泛性焦虑症，进食障碍，痴呆症，恐慌症，睡眠障碍，胃肠道疾病，运动障碍，内分泌失调，血管痉挛和性功能障碍的人或动物的方法，使用任何化合物，药物组合物和制备化合物的方法

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emPDE4B/em gene polymorphism in Russian patients with panic disorder

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