...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of affective disorders >Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder.
【24h】

Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder.

机译：甘丙肽基因的多态性与患有恐慌症的女性患者的症状严重程度有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Galanin (GAL) is a neuropeptide, which is expressed primarily in limbic nuclei in the brain and mediates miscellaneous physiological processes and behaviors. In animal studies, both the application of GAL and antagonism of its receptors have been shown to affect anxiety-like and depression-related behavior. In humans, intravenous administration of the neuropeptide galanin has been reported to have fast antidepressant efficacy. Furthermore, GAL is involved in hypothalamic-hypophysiotropic signalling and cosecreted with luteinizing hormone-releasing hormone (LHRH), possibly acting as a mediator of estrogen action. METHODS: In this study six single nucleotide polymorphisms (SNPs) within the gene coding for GAL were analyzed for possible associations with diagnosis and severity of symptoms in 121 male and female patients suffering from panic disorder (PD). RESULTS: Our results suggest an association between genetic variations in the GAL-gene and severity of PD-symptoms in female patients. The most pronounced effects could be observed for two haplotypes containing the closely linked, non-protein-coding SNPs rs948854 and rs4432027. Both polymorphisms are located within CpG-dinucleotides in the promoter region of GAL and thus might be involved in epigenetic regulation of the GAL-gene. LIMITATIONS: A relatively small patient sample was analyzed in this study, the herein presented results need to be validated in independent studies. CONCLUSIONS: The results of this study underline the potential of further genetic research concerning GAL and a possible role of this neuropeptide in the pathogenesis of female PD. In this regard, GAL and its receptors appear to be a promising target for pharmacological therapy of anxiety and affective disorders.
机译：背景：甘丙肽（GAL）是一种神经肽，主要在大脑的边缘核中表达，并介导其他生理过程和行为。在动物研究中，GAL的应用及其受体的拮抗作用已显示会影响焦虑症和抑郁症相关行为。在人类中，据报道静脉内施用神经肽甘丙肽具有快速的抗抑郁功效。此外，GAL参与下丘脑-促低体信号传导，并与促黄体激素释放激素（LHRH）共同分泌，可能充当雌激素作用的介体。方法：在这项研究中，分析了GAL编码基因中的6个单核苷酸多态性（SNP），以分析121例男性和女性恐慌症（PD）患者的诊断和症状严重程度。结果：我们的结果表明女性患者GAL基因的遗传变异与PD症状的严重程度之间存在关联。对于包含紧密连接的非蛋白质编码SNP rs948854和rs4432027的两个单倍型，可以观察到最明显的影响。两种多态性均位于GAL启动子区域的CpG-二核苷酸内，因此可能参与GAL基因的表观遗传调控。局限性：本研究中分析了相对较小的患者样本，此处提出的结果需要在独立研究中进行验证。结论：这项研究的结果强调了有关GAL的进一步遗传研究的潜力以及该神经肽在女性PD发病机理中的可能作用。在这方面，GAL及其受体似乎是焦虑和情感障碍的药物治疗的有希望的靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号