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Drosophila as a model for chromosomal instability

机译:果蝇果蝇作为染色体不稳定性的模型

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Chromosomal instability (CIN) is a common feature of tumours that leads to increased genetic diversity in the tumour and poor clinical outcomes. There is considerable interest in understanding how CIN comes about and how its contribution to drug resistance and metastasis might be counteracted. In the last decade a number of CIN model systems have been developed in Drosophila that offer unique benefits both in understanding the development of CIN in a live animal as well as giving the potential to do genome wide screens for therapeutic candidate genes. This review outlines the mechanisms used in several Drosophila CIN model systems and summarizes some significant outcomes and opportunities that they have produced.
机译:染色体不稳定(CIN)是肿瘤的共同特征,导致肿瘤中遗传多样性的增加和临床预后不良。人们对了解CIN是如何产生的以及如何抵消其对耐药性和转移的贡献非常感兴趣。在过去的十年中,在果蝇中开发了许多CIN模型系统,这些系统不仅在了解活体动物中CIN的发展方面具有独特的优势,而且还具有对治疗性候选基因进行全基因组筛选的潜力。这篇综述概述了果蝇CIN模型系统中使用的机制,并总结了它们产生的一些重要成果和机会。

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