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Analysis of class 2 integrons as a marker for multidrug resistance among Gram negative bacilli

机译：革兰氏阴性杆菌中2类整合素作为多药耐药性标记的分析

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Class 1 and 2 integrons are considered the paradigm of multidrug resistant (MDR) integrons. Although class 1 integrons have been found statistically associated to Enterobacteriaceae MDR isolates, this type of study has not been conducted for class 2 integrons. and 3 species that were found that harbored more than 20% of class 2 integrons in clinical isolates, were selected to determine the role of intI2 as MDR marker. A total of 234 MDR/191 susceptible non-epidemiologically related isolates were analyzed. Seventy-four intI2 genes were found by PCR and sequencing. An intI2 relationship with MDR phenotypes in Acinetobacter baumannii and Enterobacter cloacae was found. No statistical association was identified with MDR E. coli and Helicobacter pylori isolates. In other words, the likelihood of finding intI2 is the same in susceptible and in MDR E. coli and H. pylori strains, suggesting a particular affinity between the mobile element Tn7 and some species. The use of intI2 as MDR marker was species-dependent, with fluctuating epidemiology at geographical and temporal gradients. The use of intI2 as MDR marker is advisable in A. baumannii , a species that can reach high frequencies of this genetic element.
机译：1类和2类整合素被视为耐多药（MDR）整合素的范例。尽管已发现1类整合素在统计上与肠杆菌科MDR分离物有关，但尚未对2类整合素进行此类研究。选择了3种在临床分离物中具有20％以上2类整合素的物种，以确定intI2作为MDR标记的作用。总共分析了234份MDR / 191易感非流行病学相关分离株。通过PCR和测序发现了74个intI2基因。在鲍曼不动杆菌和阴沟肠杆菌中发现了与MDR表型的intI2关系。没有发现与MDR大肠杆菌和幽门螺杆菌分离株有统计学联系。换句话说，在易感性菌株和MDR大肠杆菌和幽门螺杆菌菌株中发现intI2的可能性是相同的，这表明可移动元件Tn7与某些物种之间具有特定的亲和力。使用intI2作为MDR标记物取决于物种，流行病学在地理和时间梯度上波动。在鲍曼不动杆菌中建议使用intI2作为MDR标记，鲍曼不动杆菌可以达到这种遗传元件的高频率。

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