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首页> 外文期刊>AIMS Genetics >Telomeres, species differences, and unusual telomeres in vertebrates: presenting challenges and opportunities to understanding telomere dynamics
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Telomeres, species differences, and unusual telomeres in vertebrates: presenting challenges and opportunities to understanding telomere dynamics

机译：脊椎动物的端粒，物种差异和不常见的端粒：提出挑战和机遇以了解端粒动力学

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There has been increasing interest in the use of telomeres as biomarkers of stress, cellular ageing and life-histories. However, the telomere landscape is a diverse feature, with noticeable differences between species, a fact which is highlighted by the unusual telomeres of various vertebrate organisms. We broadly review differences in telomere dynamics among vertebrates, and emphasize the need to understand more about telomere processes and trends across species. As part of these species differences, we review unusual telomeres in vertebrates. This includes mega-telomeres, which are present across a diverse set of organisms, but also focusing on the unusual telomeres traits of marsupials and monotremes, which have seen little to no prior discussion, yet uniquely stand out from other unusual telomere features discovered thus far. Due to the presence of at least two unique telomere features in the marsupial family Dasyuridae, as well as to the presence of physiological strategies semelparity and torpor, which have implications for telomere life-histories in these species, we suggest that this family has a very large potential to uncover novel information on telomere evolution and dynamics.
机译：使用端粒作为应激，细胞衰老和生活史的生物标志物已引起越来越多的兴趣。然而，端粒景观是一个多样化的特征，物种之间存在明显差异，这一事实在各种脊椎动物的不寻常端粒中得到了突出显示。我们广泛地审查了脊椎动物之间端粒动力学的差异，并强调需要更多地了解端粒的过程和物种间的趋势。作为这些物种差异的一部分，我们回顾了脊椎动物中不常见的端粒。这包括存在于各种生物体中的巨型端粒，但也着眼于有袋动物和单体的不寻常的端粒特征，这些特征几乎没有经过讨论，但与迄今发现的其他不寻常的端粒特征不同。由于有袋动物科Dasyuridae中至少存在两个独特的端粒特征，以及生理策略separparity和torpor的存在，这对这些物种的端粒生活史具有重要意义，因此我们建议该家族具有揭示端粒进化和动力学的新信息的巨大潜力。

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