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Role of some epigenetic factors in DNA damage response pathway

机译:一些表观遗传因素在DNA损伤反应途径中的作用

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The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chromatin since the compact chromatin structure poses a major limitation in the DNA repair process. Based on this hypothesis, our laboratory has also evaluated certain histone deacetylase inhibitors as potential radiomitigators and the same has been discussed in brief at the end of the review.
机译:本综述简要介绍了DNA损伤反应途径以及DNA损伤反应途径中各种表观遗传机制的参与。由于致密的染色质结构在DNA修复过程中存在主要局限性,因此主要关注于导致染色质结构改变的组蛋白修饰。基于此假设,我们的实验室还评估了某些组蛋白脱乙酰基酶抑制剂作为潜在的放射缓解剂,并且在本综述的结尾处对此进行了简要讨论。

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