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METHODS FOR EXPLOITING SYNTHETIC LETHALITY AND CHEMO-SENSITISATION IN DNA DAMAGE RESPONSE (DDR) PATHWAYS
METHODS FOR EXPLOITING SYNTHETIC LETHALITY AND CHEMO-SENSITISATION IN DNA DAMAGE RESPONSE (DDR) PATHWAYS
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机译：DNA损伤反应（DDR）途径中探索合成性和化学敏感性的方法
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摘要
The present invention relates to methods for exploiting synthetic lethality and chemosensitisation in tumours defective in DNA damage response pathways or that are resistant to platinum-based chemotherapies. In particular the invention relates to the ubiquitin hydrolase protein Ubiquitin Specific Protease 11 (USPll) and its association with DNA damage response pathways and / or use in the treatment of tumours that are drug-resistant to platinum-based chemotherapy. The invention further relates to methods of screening subjects for suitability of treatment with USPll inhibitors and the use of USPll inhibitors in the treatment of cancer. Further, the invention relates to the use of USPll inhibitors with anti-tumour therapeutic agents in treating cancer, as a sensitising agent.
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