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Con: Can neuropathology really confirm the exact diagnosis?

机译:缺点:神经病理学真的可以确认确切的诊断吗?

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Clinical diagnostic accuracy using revised consensus criteria and newly developed biomarkers ranges from 65 to 96% for Alzheimer's disease (AD), with a diagnostic specificity versus other dementias of 23 to 88%. Neuropathological assessment using molecular biology and immunohistochemistry, homogeneous definitions, harmonized interlaboratory methods, and assessment standards can identify 54 to 97% of AD cases and can eliminate 62 to 100% of nondemented subjects, but only between 8 and 42% of non-AD dementias, without, however, being able to clarify the etiology of most of these disorders. The value and pitfalls of pathological diagnostic criteria are critically discussed.
机译:使用修订的共识标准和新开发的生物标记物对阿尔茨海默氏病(AD)的临床诊断准确性范围为65%至96%,相对于其他痴呆症的诊断特异性为23%至88%。使用分子生物学和免疫组织化学,均一的定义,统一的实验室间方法和评估标准进行神经病理学评估,可以识别出54%至97%的AD病例,并且可以消除62%至100%的非痴呆症患者,但只能消除8%至42%的非AD痴呆症,但是无法阐明大多数此类疾病的病因。严格讨论了病理诊断标准的价值和陷阱。

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