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首页> 外文期刊>Alzheimer s Research & Therapy >Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute toneuroprotection in a traumatic brain injury
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Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute toneuroprotection in a traumatic brain injury

机译：参与PPAR和PI3K / AKT / PTEN途径的饮食可能在创伤性脑损伤中有助于保护神经

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摘要

Traumatic encephalopathy has emerged as a significant public health problem. Itis believed that traumatic encephalopathy is caused by exposure to repetitivebrain trauma prior to the initial symptoms of neurodegenerative disease.Therefore, prevention is important for the disease. The PI3K/AKT/PTEN(phosphoinositide-3 kinase/AKT/phosphatase and tensin homologue deleted onchromosome 10) pathway has been shown to play a pivotal role in neuroprotection,enhancing cell survival by stimulating cell proliferation and inhibitingapoptosis. PTEN negatively regulates the PI3K/AKT pathways through its lipidphosphatase activity. Although PTEN has been discovered as a tumor suppressor,PTEN is also involved in several other diseases, including diabetes andAlzheimer’s disease. Dietary fish oil rich in polyunsaturated fatty acidsmay induce the PTEN expression by activation of peroxisomeproliferator-activated receptor. Supplementation of these natural compounds mayprovide a new therapeutic approach to the brain disorder. We review recentstudies on the features of several diets and the signaling pathways involved intraumatic encephalopathy.
机译：创伤性脑病已成为一个重大的公共卫生问题。据认为，外伤性脑病是由于在神经退行性疾病的最初症状之前暴露于重复性脑外伤引起的。因此，预防对该病很重要。 PI3K / AKT / PTEN（磷酸肌醇-3激酶/ AKT /磷酸酶和张力蛋白同源物在染色体10上缺失）途径已被证明在神经保护中起关键作用，通过刺激细胞增殖和抑制细胞凋亡来提高细胞存活率。 PTEN通过其脂质磷酸酶活性负调控PI3K / AKT途径。尽管已发现PTEN可以抑制肿瘤，但PTEN还涉及其他几种疾病，包括糖尿病和阿尔茨海默氏病。富含多不饱和脂肪酸的膳食鱼油可通过过氧化物酶体增殖物激活受体的激活来诱导PTEN表达。补充这些天然化合物可为脑部疾病提供一种新的治疗方法。我们综述了几种饮食的特征和涉及房内脑病的信号通路的最新研究。

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