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首页> 外文期刊>Beni-Suef University Journal of Basic and Applied Sciences >Biosynthesis of size controlled silver nanoparticles by Fusarium oxysporum, their antibacterial and antitumor activities
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Biosynthesis of size controlled silver nanoparticles by Fusarium oxysporum, their antibacterial and antitumor activities

机译： oxysporum 生物合成大小可控的银纳米颗粒，其抗菌和抗肿瘤活性

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摘要

The biosynthesis method is thought to be clean, nontoxic and environmentally acceptable. Many microorganisms produce extracellular or intracellular metal nanoparticles with different efficiency, size and shape. The goal in this study is to control the size of silver nanoparticles. The preliminary screening of microorganisms,Fusarium oxysporumwas selected to control size of silver nanoparticles. Parametric optimization showed smallest particle size whenF.?oxysporumtreated with 10?2??M silver nitrate (metal ion concentration) at 50°C with 11?g wet biomass at pH6 when fungal age 7 days when incubated for 72?h silver nanoparticles produced was characterized by TEM which revealed the formation of spherical, well-dispersed nanoparticles with size between 5 and 13?nm and FTIR gives the bands at 1619 and 1392.5 corresponding to the binding vibration of amide I and II bands of proteins, respectively. Antibacterial activity againstEscherichia coliandStaphylococcus aureusshowed maximum zone of inhibition of 2?mm and 1.6?mm, respectively, at 80?μL of silver nanoparticles. Cytotoxic activity was expressed as IC50that is found to be 121.23?μgcm?3.
机译：生物合成方法被认为是清洁的，无毒的并且是环境可接受的。许多微生物产生具有不同效率，大小和形状的细胞外或细胞内金属纳米颗粒。这项研究的目的是控制银纳米颗粒的大小。为了控制银纳米颗粒的大小，选择了微生物的初步筛选。当在真菌环境中孵育72？h的银纳米颗粒时，用10？2？M的硝酸银在50°C用11？g的湿生物质在pH6下处理11天的湿生物质时，参数优化显示最小的粒径。通过TEM表征，揭示了球形的，分散的纳米颗粒的形成，其大小在5和13？nm之间，并且FTIR给出了在1619和1392.5处的带，分别对应于蛋白质的酰胺I和II带的结合振动。在80μL的银纳米颗粒上，对大肠杆菌和金黄色葡萄球菌的抗菌活性分别显示出最大抑制区分别为2？mm和1.6？mm。细胞毒性活性表示为IC 50，发现为121.23μg·cm 3。

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