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首页> 外文期刊>American journal of agricultural and biological sciences >ANTIDEPRESSANT-LIKE EFFECTS OF SELECTED CRUDE EXTRACTS OF PILEA MICROPHYLLA IN MICE MODEL OF DEPRESSION | Science Publications
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ANTIDEPRESSANT-LIKE EFFECTS OF SELECTED CRUDE EXTRACTS OF PILEA MICROPHYLLA IN MICE MODEL OF DEPRESSION | Science Publications

机译：精选小毛PI粗提物在小鼠抑郁模型中的抗抑郁药作用科学出版物

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> The present study was undertaken to investigate the effect of selected crude extracts namely, Methanol (ME I), Chloroform Extract (CE II) and Ethyl Acetate (EAE II) extracts of Pilea microphylla on depression in mice. In the present study, the antidepressant effect of P. microphylla was examined due to its rich flavonoid contents in the Urticaceae family using two behavioral models, the Forced Swimming Test (FST) and Tail Suspension Test (TST) in mice. Selected crude extracts from Pilea microphylla produced an antidepressant-like effect, since the acute treatment of mice with extracts by intraperitoneal (i.p.) route significantly reduced the immobility time in the FST (50 and 100 mg kg-1) and TST (50 and 100 mg kg-1), as compared to positive controls (haloperidol and fluoxetine) at 1 and 10 mg kg-1, respectively. The results showed that ME I, CE II and EAE II at dose of 100 mg kg-1 of body weight decreased immobility time with the increase swimming time with respect to the first day (p<0.05). Among all the three selected extracts with two doses administered there were differences compared to the control group, EAE II led to reduction of immobility time, in the FST method by 38.50% for 50 mg kg-1 to as much as 75.97% for 100 mg kg-1. Similar results of increased antidepressant effect, that was, of immobility time depending on the concentration administered, were obtained with the TST method. However, EAE II and CE II extract at dose of 100 mg kg-1 were obtained as best to choose an antideprssant activity. However, amounts of phenolic and flavonoid groups were found in CE II extract. As a conclusion treatment using selected crude extracts of P. microphylla had an antidepressant-like effect across models. Reduced immobility and decreasing freezing were observed in FST and TST tests. Therefore, P. microphylla may be served as a potential resource for natural psychotherapeutic agent against depression. The present study clearly demonstrated that Pilea microphylla exerts an antidepressant effect in these two behavioural models. It may be due to present of flavonoids. This is consistent with the hypothesis that enhanced uptake of flavonoids groups might have antidepressant-like effects. However, further studies are still required.
机译： >进行本研究以研究选定的小提香树（Pilea microphylla）的甲醇提取物（ME I），氯仿提取物（CE II）和乙酸乙酯（EAE II）提取物的作用在小鼠抑郁症。在本研究中，iP的抗抑郁作用。由于使用了两种行为模型，即小鼠的强迫游泳测试（FST）和尾巴悬吊测试（TST），对荨麻科中的小叶黄酮含量较高进行了检查。精选的来自 Pilea microphylla 的粗提取物产生了抗抑郁样作用，因为通过腹膜内（ip）途径对提取物进行急性处理可显着降低FST的固定时间（50和100 mg kgsup > -1 ）和TST（50和100 mg kg -1 ），而阳性对照（氟哌啶醇和氟西汀）分别为1和10 mg kg -1 。结果表明，与第一天相比，体重为100 mg kg -1 的ME I，CE II和EAE II减少了不动时间，并且增加了游泳时间（p <0.05）。与对照组相比，三种选择的两次给药的提取物均存在差异，EAE II导致固定时间缩短，FST法中50 mg kg -1 降低了38.50％。 100 mg kg -1 高达75.97％。用TST方法获得了相似的抗抑郁作用增强结果，即固定时间取决于给药浓度。然而，最好选择100 mg kg -1 的EAE II和CE II提取物来选择抗抑郁活性。但是，在CE II提取物中发现了一定数量的酚基和类黄酮基团。作为结论处理，使用选定的iP粗提取物。小叶菊在各个模型中均具有抗抑郁样作用。在FST和TST测试中观察到固定性降低和冷冻降低。因此， P。小叶可能被用作抗抑郁的天然心理治疗剂的潜在资源。本研究清楚地证明了 Pilea microphylla 在这两种行为模型中均具有抗抑郁作用。这可能是由于存在类黄酮。这与以下假设一致：黄酮类化合物的摄取增加可能具有抗抑郁样作用。但是，仍然需要进一步的研究。

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