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Antidepressant-Like Activity of Banana Peel Extract in Mice | Science Publications

机译：香蕉皮提取物对小鼠的抗抑郁活性科学出版物

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> Problem statement: Depressed mood, loss of interest or pleasure, feeling guilty, low selfesteem, sleep disturbance, loss of appetite, low energy and poor concentration are the characteristics of depression. This common mental disorder can occur in anyone regardless of genders, ages and backgrounds. People counteract it with psychotherapy and medications. Alternatively, some patients use herbal remedies as treatments. Recently, natural herbal products that have antidepressant effect has gain more attention in the market. Banana peel is commonly used to treat warts, as diuretics, aids in detoxification and relive hangovers. This research was conducted to study the effects of banana peel extract against depression. Approach: Swiss Albino mice were used in this study. Acute Toxicity Study (ATS) was being carried out by injecting 4 doses of the green and yellow banana peel extract each to different mice groups. Six groups of mice were treated with different treatments (normal saline 5 mL kg-1, green banana peel extract 200 and 400 mg kg-1, yellow banana peel extract 200 and 400 mg kg-1, Fluoxetine HCl 20mg kg-1, p.o.) for 7 consecutive days before mice were subjected for Forced Swim Test (FST) and Tail Suspension Test (TST). Results: The result shows that green banana peel extract 400 mg kg-1 significantly reduces the duration of immobility (p0.01) compared to control in FST. In TST, green banana peel extract 400 mg kg-1 and yellow banana peel extract (200 and 400 mg kg-1) showed significant result (p0.001) compared to control. There were no signs of acute toxicity observed for the extracts in ATS. Conclusion/Recommendations: This research suggested that the banana peel extracts exhibits antidepressant-like effects. Further studies maybe conducted on locomotor activity study and phytochemical screening.
机译： > 问题陈述：抑郁的特征是情绪低落，失去兴趣或享乐，感到内，自卑，睡眠障碍，食欲不振，精力不足和注意力不集中。不论性别，年龄和背景，任何人都可能发生这种常见的精神障碍。人们用心理疗法和药物来抵消它。或者，一些患者使用草药作为治疗方法。近来，具有抗抑郁作用的天然草药产品在市场上越来越受到关注。香蕉皮通常用作治疗疣的利尿剂，有助于排毒和缓解宿醉。进行该研究以研究香蕉皮提取物对抑郁症的作用。 方法：本研究使用了瑞士白化病小鼠。急性毒性研究（ATS）通过分别向不同的小鼠组注射4剂绿色和黄色香蕉皮提取物进行。六组小鼠接受了不同的处理（生理盐水5 mL kg -1 ，绿色香蕉皮提取物200和400 mg kg -1 ，黄色香蕉皮提取物200和400 mg kg -1 ）。连续7天将400 mg kg -1 ，盐酸氟西汀20mg kg -1 ，po）连续7天，然后再对小鼠进行强迫游泳测试（FST）和尾巴悬吊测试（TST） ）。 结果：结果表明，与FST对照组相比，绿色香蕉皮提取物400 mg kg -1 显着减少了固定时间（p <0.01）。在TST中，绿色香蕉皮提取物400 mg kg -1 和黄色香蕉皮提取物（200 mg和400 mg kg -1 ）显示出显着的结果（p <0.001）控制。在ATS中没有观察到提取物的急性毒性迹象。 结论/建议：该研究表明香蕉皮提取物具有抗抑郁样作用。可能会进行运动活性研究和植物化学筛选方面的进一步研究。

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