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首页> 外文期刊>American Journal of Analytical Chemistry >RP-HPLC Method for the Simultaneous Determination of Lisinopril and NSAIDs in API, Pharmaceutical Formulations and Human Serum
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RP-HPLC Method for the Simultaneous Determination of Lisinopril and NSAIDs in API, Pharmaceutical Formulations and Human Serum

机译：RP-HPLC法同时测定API，药物制剂和人血清中的赖诺普利和非甾体抗炎药

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摘要

High performance liquid chromatographic method was developed valdated and applied for the simultaneous determi- nation of lisinopril and NSAIDs in bulk, pharmaceuticals formulations and human serum. A Purospher star C18 (5 μm, 25 × 0.46 cm) column was used with mobile phase consisting of methanol: water: acetonitrile (80:17.5:2.5 v/v, pH 3.0) and quantitative evaluation was performed at 225 nm with a flow rate of 1.0 mL?min–1. The retention time of lisinopril was 2.2 min while naproxen, flurbiprofen, diclofenac sodium and mefenamic acid were found to be 4.0, 4.5, 5.0 and 6.7 min respectively. Suitability of this method for the quantitative determination of the drugs was proved by validation in accordance with the requirements laid down by International Conference on Harmonization (ICH) guidelines. The method is selective, precise, accurate and can be used for analysis of pharmaceutical preparations in quality control and clinical laboratories.
机译：已开发出一种高效液相色谱方法，该方法已验证可用于批量测定赖诺普利和非甾体抗炎药，药物制剂和人血清的含量。使用Purospher star C18（5μm，25×0.46 cm）色谱柱，流动相由甲醇：水：乙腈（80：17.5：2.5 v / v，pH 3.0）组成，并在225 nm流速下进行定量评估速度为1.0 mL？min-1。赖诺普利的保留时间为2.2分钟，而萘普生，氟比洛芬，双氯芬酸钠和甲芬那酸的保留时间分别为4.0、4.5、5.0和6.7分钟。根据国际协调会议（ICH）指南规定的要求，通过验证证明了该方法对药物定量测定的适用性。该方法具有选择性，精确，准确，可用于质量控制和临床实验室中药物制剂的分析。

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