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首页> 外文期刊>Alzheimer s Research & Therapy >Prospective associations between pulse pressure and cognitive performance in Chinese middle-aged and older population across a 5-year study period
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Prospective associations between pulse pressure and cognitive performance in Chinese middle-aged and older population across a 5-year study period

机译：在为期5年的研究中，中国中老年人群的脉压与认知能力之间的前瞻性关联

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Substantial evidence indicates that the relationship between blood pressure (BP) measures and cognitive functioning is inconsistent, complex, and age-related. Pulse pressure (PP), which can not only reflect arterial stiffness and but also represent the chronic effects of hypertension other than BP itself, has been considered as a better predictor of cognitive impairment. However, evidence on the association of cognitive function with PP has not been investigated extensively. We examined this relationship in a longitudinal study based on the latent growth model (LGM). This study was based on a nationally representative sample of Chinese middle-aged and older participants from the China Health and Retirement Longitudinal Study (CHARLS), a prospective observational study conducted from 2011 to 2016. Cognitive performance was assessed on the basis of three measures of cognition. The PP was calculated as the difference of the average values of three systolic and diastolic BP readings. A series of potential confounders were collected in this research. The LGM was used to examine the effects of PP on cognitive performance at three time points. To test the independent effects of PP on the initial level and the subsequent development of cognition, unconditional and conditional models were compared sequentially. After excluding respondents with missing key variables, we ultimately included 9750 participants in the analysis. Cognitive performance scores and PP showed significant differences across time. After adjustment for the confounders, the standardized coefficients of PP in the LGM indicated negative effects on cognitive performance in elderly Chinese participants at wave 2 and wave 3 (P < 0.01). The initial level of PP in the unconditional model was negatively associated with the initial level (β = ??0.25) and the slope (β = ??0.16) of cognition, whereas these effects were attenuated and the association between intercept of PP and slope of cognition became nonsignificant after controlling for the confounders. The implications of these results demonstrate that a higher PP lowers the cognitive performance of middle-aged and elderly persons independent of a comprehensive set of covariates, but it is not a contributor to the rate of change in cognition.
机译：大量证据表明，血压（BP）措施与认知功能之间的关系不一致，复杂且与年龄有关。脉压（PP）不仅可以反映动脉僵硬，而且可以代表除BP本身以外的高血压的慢性影响，已被认为是认知障碍的较好预测指标。但是，关于认知功能与PP的关联的证据尚未得到广泛研究。我们在基于潜在增长模型（LGM）的纵向研究中检查了这种关系。这项研究基于中国健康与退休纵向研究（CHARLS）的全国代表性中国中老年参与者的样本，该研究是2011年至2016年进行的一项前瞻性观察性研究。基于以下三种方法对认知表现进行了评估：认识。 PP计算为三个收缩压和舒张压BP读数的平均值之差。这项研究收集了一系列潜在的混杂因素。 LGM用于在三个时间点检查PP对认知表现的影响。为了测试PP对初始水平和随后的认知发展的独立影响，先后比较了无条件和条件模型。在排除缺少关键变量的受访者之后，我们最终在分析中纳入了9750名参与者。认知表现得分和PP随时间变化显着。在对混杂因素进行调整之后，LGM中PP的标准化系数表明在第2浪和第3浪对中国老年参与者的认知能力产生负面影响（P <0.01）。在无条件模型中，PP的初始水平与认知的初始水平（β= 0.25）和斜率（β= 0.16）呈负相关，而这些影响被减弱并且PP的截距与斜率之间存在关联控制混杂因素后，认知能力变得不重要了。这些结果的含义表明，较高的PP会降低中老年人的认知能力，而与一组完整的协变量无关，但它并不能促进认知变化率。

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