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首页> 外文期刊>PLoS One >Prospective association between sleep-related factors and the trajectories of cognitive performance in the elderly Chinese population across a 5-year period cohort study
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Prospective association between sleep-related factors and the trajectories of cognitive performance in the elderly Chinese population across a 5-year period cohort study

机译：睡眠相关因素与年长中国人口认知性能轨迹的前瞻性关系

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The integral role of sleep in cognition, such as night-time sleep and napping duration, has yielded mixed findings, especially in healthy elderly adults. This study aimed to identify the heterogeneous classes of the cognitive trajectories and investigated the associations between sleep parameters and the trajectories of cognition in different elderly subpopulations. The study was based on a large, national representative sample aged 60 years or older. Two cognitive measures were assessed, including executive function and episodic memory. Sleep parameters were evaluated, including post-lunch napping, night-time sleep duration, and sleep disturbances. Latent growth mixture model (LGMM) was used to describe the trajectories of cognition and investigate the effects of sleep factors on cognition. Three heterogeneous trajectories were identified for executive cognition and four for episodic memory. Inverted U-shape associations of cognition with night-time sleep and napping duration were found. In LGMM, night-time sleep duration was negatively associated with the baseline episodic memory in elderly adults. Post-lunch napping was positively associated with the baseline executive function ( β = 0.078, P 0.05) and episodic memory ( β = 0.084, P 0.05) in men, whereas it was only associated with impaired episodic memory ( β = -0.152, P 0.05) in women. Frequent sleep disturbances were only associated with the impaired executive function at baseline ( β = -0.088, 95%CI -0.162, -0.013) among older men. Overall, sleep parameters played different roles in heterogeneous trajectories of cognition by sex difference. Sleep factors may not be related to the rate of cognition decline, but these factors, independent of time-variant depressive symptoms, were associated with the initial status of cognition at baseline.
机译：睡眠在认知中的积分作用，例如夜间睡眠和清醒持续时间，产生了混合发现，特别是在健康的老年人身上。本研究旨在识别认知轨迹的异构类别，并研究了睡眠参数与不同老年群体中认知轨迹的关联。该研究基于60岁或以上的大型国家代表性样本。评估了两项认知措施，包括执行功能和情节记忆。评估睡眠参数，包括午餐后午睡，夜间睡眠持续时间和睡眠干扰。潜在生长混合模型（LGMM）用于描述认知的轨迹，并调查睡眠因素对认知的影响。为行政认知和四个情节记忆进行了三种异质轨迹。发现了认知与夜间睡眠和小睡持续时间的倒的U形关联。在LGMM中，夜间睡眠持续时间与老年人的基线情节记忆负相关。午餐后初步与男性的基线执行功能（β= 0.078，P＆ 0.05）和情节内存（β= 0.084，P <0.05）呈正相关，而它仅与障碍障碍障碍有关（β= -0.152，p <0.05）妇女。频繁的睡眠扰动只与年龄较大的男性基线（β= -0.088,95％CI -0.162，-0.013）的执行功能有关。总体而言，睡眠参数在性别差异中对认知的异质轨迹起不同的作用。睡眠因素可能与认知率下降不相关，但这些因素与时变抑郁症状无关，与基线的认知初始状态有关。

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