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首页> 外文期刊>American Journal of Analytical Chemistry >Fast and Sensitive Chiral Analysis of Amphetamines and Cathinones in Equine Urine and Plasma Using Liquid Chromatography Tandem Mass Spectrometry
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Fast and Sensitive Chiral Analysis of Amphetamines and Cathinones in Equine Urine and Plasma Using Liquid Chromatography Tandem Mass Spectrometry

机译：液相色谱-串联质谱法快速，灵敏地分析马尿液和血浆中的苯丙胺和卡西酮

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摘要

A simple, rapid, sensitive and reproducible method for enantiomer analysis of methamphetamine, amphetamine, cathinone and methcathinone was developed and validated. The compounds were extracted from equine plasma and urine using a fast liquid-liquid extraction procedure. Only one milliliter plasma and one hundred microliter urine sample is needed for analysis. The extraction procedure had good recovery (>70%) and the matrix effect was negligible. Enantiomer differentiation and confirmation were achieved using liquid chromatography with chiral stationary phase and mass spectrometry detection. The method demonstrated excellent reproducibility with intra-day and inter-day precision of lower than 5%. The lower limits of detection for all of the compounds studied here were at low pg/mL level for both plasma and urine. This is the first report of the analysis of four chiral compounds in equine plasma and urine. Routine application was demonstrated for (S)- and (R)-enantiomer differentiation.
机译：开发并验证了一种简单，快速，灵敏且可重现的甲基苯丙胺，苯丙胺，卡西酮和甲卡西酮对映体分析方法。使用快速液-液提取程序从马血浆和尿液中提取化合物。分析仅需要一毫升血浆和一百微升尿液样本。萃取过程具有良好的回收率（> 70％），且基质效应可忽略不计。使用具有手性固定相的液相色谱和质谱检测，可实现对映体的区分和确认。该方法具有出色的重现性，日内和日间精度低于5％。此处研究的所有化合物的血浆和尿液的检测下限均为低pg / mL水平。这是马血浆和尿液中四种手性化合物分析的第一份报告。已证实常规应用可用于（S）-和（R）-对映异构体分化。

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